The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of Glipizide. An anti-diabetic drug, Glipizide, is delivered through the microparticulate system using ethyl cellulose as the controlled release polymer. Microspheres were developed by the emulsion solvent diffusion-eva...

Structural modifications of the multipotential carcinogen ethyl carbamate (urethan), CH3CH2—O---CO—-NH2, generally result in dramatic losses of carcinogenic activity, which usually have been assayed by lung adenoma induction and by initiation of skin papillomas in mice (reviewed in Refs. 12 and 20). One exception is ethyl N-hydroxycanbamate, CH3CH2— O—CO—-NHOH, a metabolite of ethyl c...

A large scale isolation of a disaccharide from a dialyzable fraction cf Micrococcus Zysodeikticus cell wall is described. This fraction was obtained by degradation of isolated walls with egg white lysozyme. After purification by chromatography on charcoal-Celite 2nd Dowex 1, the compound was characterized by a crystalline heptaacetyl methyl ester. Comparison with synthetic 0-2-acetamido-2-deoxy...

OBJECTIVE To study the safety and surgical time required when using the tissue adhesive 2-ethyl-cyanoacrylate compared with conventional suture in upper lid blepharoplasty. METHOD A retrospective study was performed on 40 eyes of 20 patients who underwent bilateral upper lid blepharoplasty. In 7 patients, continuous non-absorbable suture (6-0 nylon monofilament Ethilon(®), Ethicon Inc., Somer...

The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microballoons of Propranolol hydrochloride. An antihypertensive drug, Propranolol hydrochloride, is delivered through the microparticulate system using ethyl cellulose as the controlled release polymer. Microballoons were developed ...

A large scale isolation of a disaccharide from a dialyzable fraction cf Micrococcus Zysodeikticus cell wall is described. This fraction was obtained by degradation of isolated walls with egg white lysozyme. After purification by chromatography on charcoal-Celite 2nd Dowex 1, the compound was characterized by a crystalline heptaacetyl methyl ester. Comparison with synthetic 0-2-acetamido-2-deoxy...

Characteristic aroma volatile compounds from different parts of cayenne pineapple were analyzed by headspace-solid phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC/MS). The main volatile compounds were esters, terpenes, ketones and aldehydes. The number and content of aroma compounds detected in pulp were higher than those found in core. In pulp, the characteristic a...