Associate Editors Derek C. Angus, MD, MPH, Ethan Basch, MD, Charlene Breedlove, Anne Rentoumis Cappola, MD, ScM, Helene M. Cole, MD, Thomas B. Cole, MD, MPH, W. Gregory Feero, MD, PhD, J. Michael Gaziano, MD, MPH, Donald C. Goff, MD, Preeti N. Malani, MD, MSJ, David H. Mark, MD, MPH, Robert A. McNutt, MD, George T. O’Connor, MD, MS, Boris Pasche, MD, PhD, Eric D. Peterson, MD, MPH, Jeffrey L. S...

To solve problems of compliance, an institutional trigger mechanism is often used. This paper develops a model of two trigger mechanisms and derives conditions where the two institutions may complement one another to improve utility and compliance. When the conditions for optimality do not hold, small changes in institutional structure may create lumpy changes in behavior. Also, the paper explo...

The title complex mol-ecule, [Ni(NCS)(2)(C(11)H(10)N(2)O)(4)], has a crystallographically imposed centre of symmetry. The Ni(II) atom is coordinated by the N atoms of two trans-arranged NCS(-) anions and four 1-[4-(1H-imidazol-1-yl)phen-yl]ethan-one ligands in a distorted octa-hedral geometry. In the crystal, C-H⋯S hydrogen bonds link the complex mol-ecules into chains parallel to the b axis. T...

1 Ethan Bolker is also Professor of Computer Science at the University of Massachusetts, Boston. Intel’s recently introduced Hyper-Threading Technology (HTT) makes a single physical processor appear as two logical processors. Operating systems and applications can schedule processes or threads on those logical processors. The performance impact of HTT varies, depending on the nature of the appl...

The synthesis and the evaluation as organocatalysts of new chiral guanidines derived from benzimidazoles in the enantioselective α-amination of 1,3-dicarbonyl compounds using di-t-butylazodicarboxylate as aminating agent is herein disclosed. The catalysts are readily synthesized through the reaction of 2-chlorobezimidazole and a chiral amine in moderate-to-good yields. Among all of them, those ...

Herein we describe the synthesis and in vitro biological evaluation of thirteen new, racemic, diversely functionalized imidazo pyranotacrines as non-hepatotoxic, multipotent tacrine analogues. Among these compounds, 1-(5-amino-2-methyl-4-(1-methyl-1H-imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinolin-3-yl)ethan-1-one (4) is non-hepatotoxic (cell viability assay on HepG2 cells), a select...

The 1997 motion picture “Gattaca,” written and directed by Andrew Niccoll, is a futuristic film set in a time when society analyzes your DNA and determines where you belong in life. Ethan Hawke's character was born with a congenital heart condition, so, in turn, he assumes the identity of an athlete who has genes that would allow Hawke’s character to achieve his dream of space travel. Samples o...

In the title compound, C24H29NO3, the aza-bicycle contains two six-membered rings, viz. a cyclo-hexane ring and a piperidine ring. The first adopts a chair conformation and the second a half-chair conformation. The dihedral angle between their mean planes is 86.21 (13)°, indicating that they are almost perpendicular to one another. The dihedral angle between the planes of the 4-meth-oxy-phenyl ...

GROWTH FACTOR RECEPTOR ABUNDANCE AND DEGRADATION THROUGH UBIQUITINSPECIFIC PROTEASE 8 Cai, Jinjin, Tracy M. Crotty, Ethan Reichert, Kermit L. Carraway 3 , Diana M. Stafforini, and Matthew K. Topham From Huntsman Cancer Institute, Department of Oncological Sciences, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112. UC Davis Cancer Center, Sacramento, California 958...

Upholding ethical standards is part of what it means to be a professional and therefore part of professional education, but to what extent is the development of ethical reasoning universal across cultures, or is it highly dependent on culture? If universal, how can we explain the unique patterns of moral reasoning and behaviour in Asia, which reflect Confucian values? This issue is particularly...