To investigate the estrogenic effect of Pueraria mirifica (PM), a Thai herbal plant that contains many phytoestrogens, sexual skin coloration was studied in cynomolgus monkeys. Aged menopausal monkeys were divided into three groups. Each group (n=3) was fed 10, 100, or 1,000 mg of PM daily. The treatment schedule was divided into three periods, a 30-day pre-treatment period, 90-day treatment pe...

We show that developmental exposure of the laboratory rat to the coplanar polychlorinated biphenyl (PCB) congener 3,4,3',4'-tetrachlorobiphenyl (TCB) and the structurally similar congener 3,4,5,3',4'-pentachlorobiphenyl (PtCB) elevates dopamine (DA) concentrations in the prefrontal cortex (PFC). To determine whether these coplanar congeners are estrogenic, and may thus contribute to the elevati...

The effect of ethanolic extract of the whole plants of leptadenia reticulata has been studied in albino rats to explore it’s the anti-implantation and hormonal activities. A strong anti-implantation (inhibition 100%) and uterotropic activity was observed at the dose level of 300 mg /kg. No antiestrogenic activity could be detected. Keyword: Leptadenia reticulate; Antifertility; Anti-implantatio...

background: nelumbo nucifera has been used as antifertility agent in females by the local tribals of rajasthan especially of udaipur district india. objective: the present study was conducted to investigate the effect of nelumbo nucifera on the fertility and general physiology in female rats. materials and methods: 20 female albino rats were taken and divided into two groups. group 1 served as ...

Colchieine had a significant inhibitory influence on the leukemogenic effect of estrogenic hormone in combination with either x-ray or urethan in mice. There was some suggestion that colchicine inhibited the induction of leukemia in mice by x-rays. Colchicine was not leukemogenic in low-leukemia strains of mice when administered alone. Colchieine did not affect spontaneous (presumably viral) le...

Although the epileptogenic properties of estrogens have been widely demonstrated in several models and species, the mechanism(s) by which estrogens can acutely change seizure parameters including after discharge and seizure duration remain remains to be determined. In the present study, we examined the role of NMDA (N-methyl-D-aspartate), non-NMDA and estrogenic receptors in estradiol benzoate ...