BACKGROUND/AIMS To evaluate the characteristic properties of laryngopharyngeal reflux (LPR) and gastroesophageal reflux (GER) in children with otitis media with effusion (OME) using 24-hour multichannel intraluminal impedance combined with dual-probe (pharyngeal and esophageal) pH-metry. METHODS Children aged 7-10 years of age with OME underwent 24-hour multichannel intraluminal impedance pH-...

BACKGROUND/AIMS The impact of aging on esophageal motility is not completely understood. This study aims at assessing 1) whether degeneration of esophageal body motility occurs with age and 2) whether this development is influenced by gastroesophageal reflux disease (GERD). METHODS 326 consecutive patients with symptoms of GERD underwent a diagnostic work-up including a water-perfused esophag...

BACKGROUND Esophageal reflux and Barrett's esophagus represent two major risk factors for the development of esophageal adenocarcinoma. Previous studies have shown that brief exposure of the Barrett's-associated adenocarcinoma cell line, SEG-1, or primary cultures of Barrett's esophageal tissues to acid or bile results in changes consistent with cell proliferation. In this study, we determined ...

BACKGROUND Standard treatment for patients with erosive esophagitis (EE) is proton-pump inhibitors (PPIs), but some patients are resistant to PPIs. We aimed to evaluate the acid-inhibitory effects and efficacy of a novel potassium-competitive acid blocker (vonoprazan) in patients with PPI-resistant EE. METHODS This randomized, double-blind, multicenter study of vonoprazan evaluated gastric an...

Patients with gastroesophageal reflux may have extra-esophageal manifestations. We report a 46 years old ex-smoker woman presenting with a sensation of burning mouth, xerostomia and glossitis. The patient had a history of heartburn, dysphonia and cough. Mouth examination showed a bad hygiene and abundant accumulation of plaque. Esophageal pH measurement was abnormal. Laryngoscopy showed a poste...

OBJECTIVES Gastrointestinal symptoms, particularly pyrosis, complicate nonsteroidal anti-inflammatory drug (NSAID) use. NSAIDs cause esophageal injury, and H2 blockers are often prescribed for, and successfully control, NSAID-related symptoms. To determine whether NSAIDs can induce gastroesophageal reflux, we studied the effect of a commonly used NSAID, naproxen, on reflux parameters and esopha...

The literature review focuses on the current understanding of visceral hypersensitivity mechanisms in esophagus. Mechanisms peripheral and central sensitization their relation to heartburn symptoms are covered detail. Diagnostic criteria algorithms for non-erosive reflux disease, functional heartburn, esophagus based pH-impedance testing high-resolution esophageal manometry data presented.

Background Esophageal multichannel intraluminal impedance-pH monitoring has become one of the preferred tests to correlate observed reflux-like behaviors with esophageal reflux events. The Gastroesophageal reflux disease Assessment Symptom Questionnaire is a validated tool used to distinguish infants with gastroesophageal reflux disease from healthy children. The aim of this study was to determ...

BACKGROUND Gastroesophageal reflux and progressive esophageal dilatation can develop after gastric banding (GB). HYPOTHESIS Gastric banding may interfere with esophageal motility, enhance reflux, or promote esophageal dilatation. DESIGN Before-after trial in patients undergoing GB. SETTING University teaching hospital. PATIENTS AND METHODS Between January 1999 and August 2002, 43 patien...