This paper introduces the parallel Chinese-English Entities, Relations and Events (ERE) corpora developed by Linguistic Data Consortium under the DARPA Deep Exploration and Filtering of Text (DEFT) Program. Original Chinese newswire and discussion forum documents are annotated for two versions of the ERE task. The texts are manually translated into English and then annotated for the same ERE ta...

The history of studies of mechanisms of estrogen action in the brain is filled with at least two periods of intense dogmatic beliefs. These include thinking that a single type of cytoplasmic, unliganded estrogen receptor (ER) bound ligand and moved to the nucleus after activation (1), to thinking that all ERs were located in cell nuclei even in the unoccupied state (2). The dogma of cytoplasmic...

The species responsible for the broad extended red emission (ERE), discovered in 1975 and now known to be widespread throughout the Galaxy, still is unidentified. Spanning the range from approximately 540 to 900 nm, the ERE is a photoluminescent process associated with a wide variety of different interstellar environments. Over the years, a number of plausible candidates have been suggested, bu...

The estrogen pathway plays an important role in the etiology of human endometrial carcinoma (EC). We examined whether estrogen biosynthesis in the tumor microenvironment promotes endometrial cancer. To examine the contribution of stromal cells to estrogen signaling in EC, we used reporter cells stably transfected with the estrogen response element (ERE) fused to the destabilized green fluoresce...

TEHRAN,Iran Iranian security men, disguised as m aintenance w orkers and a doctor, yesterday overpow ered four hijackers w ho had threatened to blow up a Kuwaiti jet at Tehran’s airport and freed the rem aining hostages of the six-day o r­ deal. The gunm en, w ho had com m an­ deered the Airbus A-300 jetliner carrying 161 people on Tuesday, w ere "severely beaten u p ” during the assault, accor...

Accumulating evidence suggests that aquaporins (AQPs) may facilitate tumor development. The molecular pathways connecting the pathological functions of AQPs are unclear and need to be better defined. This study aimed to investigate whether AQP3, one of the AQPs expressed highly in breast cancer, had any clinical implication in estrogen-receptor (ER) positive breast cancer, and explore the regul...

The importance of computational methods for the simulation and analysis of biological systems has increased during the last years. In particular, methods to predict binding energies are developing not only with the aim of ranking the affinities between two or more complexes, but also to quantify the contribution of different types of interaction. In this work, we present the application of HINT...

Les moyens d’action souvent privilégiés pour la sauvegarde de planète comme sanctuarisation zones protégées et gestion production/consommation paraissent aujourd’hui insuffisants endiguer dégradation notre environnement. Nous proposons dans cette contribution une double réflexion qui vise (1) à alimenter le débat sur rapport l’Homme Nature (2) montrer comment l’art contemporain peut contribuer ...

Eutypine (4-hydroxy-3-[3-methyl-3-butene-1-ynyl] benzaldehyde) is a toxin produced by Eutypa lata , the causal agent of eutypa dieback of grapevines. Recently, a eutypine detoxifying gene (Vr-ERE ) encoding an NADPH-dependent aldehyde reductase which converts eutypine into the corresponding alcohol, eutypinol, a non-toxic form of the toxin, has been cloned. We report here the obtention of trans...

BACKGROUND The proliferating cell nuclear antigen (PCNA) is an essential component of DNA replication, cell cycle regulation, and epigenetic inheritance. High expression of PCNA is associated with poor prognosis in patients with breast cancer. The 5'-region of the PCNA gene contains two computationally-detected estrogen response element (ERE) sequences, one of which is evolutionarily conserved....