The rat estrogen receptor (ER) exists as two subtypes, ERa and ERb, which differ in the C-terminal ligand binding domain and in the N-terminal transactivation domain. In this study we investigated the messenger RNA expression of both ER subtypes in rat tissues by RT-PCR and compared the ligand binding specificity of the ER subtypes. Saturation ligand binding analysis of in vitro synthesized hum...

In the current project we focused on the synthesis of 4-Substituted-2-p-tolylthiazole derivatives. Cytotoxicity of synthesized compounds were evaluated against T47D breast cancer cell line and also all of the final compounds 3−7 were docked into the active site of c-Src and erb tyrosine kinases. Compound 4 was the most potent derivative in cytotoxicity assay (IC50 = 2.5 μg/mL) and it was also t...

Aim: of this study was to assess and compare, the radiopacity nanoparticle-based (NPB) root canal sealers with Epoxy Resin Based(ERB) sealer using an aluminium step wedge in accordance ISO 6876/2012 standards. Materials methods: The specimens, which were made each material, had a 10mm diameter 1mm thickness. creation metallic matrices, used fabrication impressions, done light-bodied silicone-ba...

Cutting-edge technological advancements have turned many electronic devices into waste within a short time of usage. Electronic (e-waste) has become global problem. Due to the adverse impact e-waste on environment and human health, regulatory system for effective collection treatment disposed by community business sectors is in dire need. In an attempt address setbacks cope with issues, this st...

Background: Fine-needle aspiration of breast cancer often provides moderate cellular material that is representative of the tumors. These samples can be used not only for cytological diagnosis but also to obtain information on the prognosis and likely response to therapy by using immunohistochemical staining studies. Methods: We assessed the degree of correlation between prognostic biologic ma...

This study applied ERB analysis for measuring acoustic correlates of hypernasal fricatives produced by speakers with different aetiologies (cleft palate, maxillectomy and dysarthria). The speech materials were consonants /n/ and /s/ segmented from two Cantonese single words and four Cantonese oral sentences. Results showed that hypernasal speakers produced /s/ with significantly higher mean amp...