نتایج جستجو برای: epothilone a
تعداد نتایج: 13431870 فیلتر نتایج به سال:
A biocatalyst is an enzyme that speeds up or slows down the rate at which a chemical reaction occurs and certain processes by 108 times. It used as anticancer agent because it targets drug activation inside tumor microenvironment while limiting damage to healthy cells. Biocatalysts have been for synthesis of different heterocyclic compounds also in nano delivery systems. The use nano-biocatalys...
A ctivate. Couple. Deprotect. Repeat. So goes the cycle of peptide synthesis, whereby amino acids are iteratively connected to produce oligopeptides. However, only peptides that are fewer than approximately 50 residues can typically be accessed through solid-phase peptide synthesis. Thus, a defining moment in the field of peptide synthesis came about with the advent of native chemical ligation ...
Despite the clinical success of microtubule-interacting agents (MIA), a significant challenge for oncologists is the inability to predict the response of individual patients with cancer to these drugs. In the present study, six cell lines were compared by 2D DIGE proteomics to investigate cellular resistance to the class of MIAs known as microtubule-stabilizing agents (MSA). The human lung canc...
Department of Immunology, Beckman Research Institute of the City of Hope, CA 91010, USA Division of Applied Life Science (BK21 Program), Systems and Synthetic Agrobiotech Center (SSAC), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), Jinju 660-701, Korea. E-mail: [email protected] Department of...
In this study, we investigated the in vitro and in vivo efficacy of patupilone (epothilone B, EPO906), a novel nontaxane microtubule stabilizing agent, in treatment of multiple myeloma (MM). Patupilone directly inhibited growth and survival of MM cells, including those resistant to conventional chemotherapies, such as the taxane paclitaxel. Patupilone induced G2M arrest of MM cells, with subseq...
Despite the clinical success of microtubule-interacting agents (MIA), a significant challenge for oncologists is the inability to predict the response of individual patients with cancer to these drugs. In the present study, six cell lines were compared by 2D DIGE proteomics to investigate cellular resistance to the class of MIAs known as microtubule-stabilizing agents (MSA). The human lung canc...
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