BACKGROUND Prostaglandin E(2) (PGE(2)) is important in ductus arteriosus (DA) patency, but the types of functional PGE(2) receptors (EP) in the developing DA are not known. We postulated that age-dependent alterations in EP and/or their subtypes may possibly contribute to the reduced responsiveness of the newborn DA to PGE(2). METHODS AND RESULTS We determined PGE(2) receptor subtypes by comp...

Ethyl pyruvate (EP), a derivative of pyruvic acid, is known to have protective effects against ischemic cardiomyopathy and other disorders. However, little is known about its role in Adriamycin (ADR)-induced cardiomyopathy. The present study was designed to investigate the impact of EP on ADR-induced cardiomyopathy in an animal model. Sixty male Sprague-Dawley (SD) rats were divided into four g...

We have reported previously that PGE(2) inhibits dendritic cells (DC) functions. Because E prostanoid receptor (EPR) subtypes involved in this action are unknown, expression and functions of these receptors were examined in DC. Western blot and flow cytometry analyses showed that all EPRs were coexpressed in DC. In a dose-dependent manner, lipopolysaccharide (LPS) enhanced EP(2)R/EP(4)R but not...

T HE CURRENT STUDY was suggested by the observation that various substances are capable of potentiating the inotropic response of the papillary muscle to epinephrine. The object of the study has been to obtain information about the nature of the action by which such substances as cysteine, cystine, tyrosine, ascorbic acid, and plasma are capable of producing this potentiation. Four possible sit...

Exercise induces increased levels of plasma interleukin-6 (IL-6) as well as changes in the concentration of lymphocytes and neutrophils. The aim of this study was to investigate a possible role for epinephrine. Seven healthy men participated in an exercise experiment. One month later they received an epinephrine infusion. The exercise consisted of treadmill running at 75% of maximal O(2) consum...

T HE CURRENT STUDY was suggested by the observation that various substances are capable of potentiating the inotropic response of the papillary muscle to epinephrine. The object of the study has been to obtain information about the nature of the action by which such substances as cysteine, cystine, tyrosine, ascorbic acid, and plasma are capable of producing this potentiation. Four possible sit...

in this paper we study the impact of minkowski metric matrix on a projection in theminkowski space m along with their basic algebraic and geometric properties.the relationbetween the m-projections and the minkowski inverse of a matrix a in the minkowski spacemis derived. in the remaining portion commutativity of minkowski inverse in minkowski spacem is analyzed in terms of m-projections as an a...

Recent results from searches for physics beyond the Standard Model (SM) in e-proton collisions at HERA at center-of-mass energies of 300 and 320 GeV are presented. They were performed on a data sample collected in the period 1994− 2004 by the H1 and ZEUS collaborations. The data have been analysed searching for leptoquarks, light gravitinos in R-parity violating supersymmetric models and magnet...

The NEMO 3 detector, now operating in the Fréjus Underground Laboratory, is devoted to search for neutrinoless double beta decay ; the expected sensitivity for the effective neutrino mass (< mν >) is on the order of 0.1 eV. The performances of the tracking detector are presented. The first and very preliminary results concerning the background and the double beta signal are given.