نتایج جستجو برای: epimastigote

تعداد نتایج: 248  

Journal: :Parasitology 2013
Cássio S Meira Elisalva T Guimarães Tanira M Bastos Diogo R M Moreira Therezinha C B Tomassini Ivone M Ribeiro Ricardo R Dos Santos Milena B P Soares

We previously observed that physalins have immunomodulatory properties, as well as antileishmanial and antiplasmodial activities. Here, we investigated the anti-Trypanosoma cruzi activity of physalins B, D, F and G. We found that physalins B and F were the most potent compounds against trypomastigote and epimastigote forms of T. cruzi. Electron microscopy of trypomastigotes incubated with physa...

Journal: :The Journal of Cell Biology 1975
J J Paulin

The unitary nature of the chondriome of two species of trypanosomatids, Blastocrithidia culicis and Trypanosoma cruzi, has been demonstrated by utilizing serial thick-sectioning techniques combined with high voltage electron microscopy. Profiles of mitochondrial elements seen in thin sections and suspected to be parts of a continuum were confirmed by serial thick sectioning (0.25-0.50 mum thick...

2012
Takeshi Annoura Takashi Makiuchi Idalia Sariego Takashi Aoki Takeshi Nara

BACKGROUND The flagellate protozoan parasite, Trypanosoma cruzi, is a causative agent of Chagas disease that is transmitted by reduviid bugs to humans. The parasite exists in multiple morphological forms in both vector and host, and cell differentiation in T. cruzi is tightly associated with stage-specific protein synthesis and degradation. However, the specific molecular mechanisms responsible...

Journal: :Genetics and molecular research : GMR 2006
A O Ericsson L O Faria W B Cruz C Martins de Sá B D Lima

In a 17-kb genomic fragment of Trypanosoma cruzi chromosome XX, we identified three tandemly linked genes coding for CX(2)CX(4)HX(4)C zinc finger proteins. We also showed that similar genes are present in T. brucei and Leishmania major, sharing three monophyletic groups among these trypanosomatids. In T. cruzi, TcZFP8 corresponds to a novel gene coding for a protein containing eight zinc finger...

2016
Raphael Souza Pavani Marcelo Santos da Silva Carlos Alexandre Henrique Fernandes Flavia Souza Morini Christiane Bezerra Araujo Marcos Roberto de Mattos Fontes Osvaldo Augusto Sant’Anna Carlos Renato Machado Maria Isabel Cano Stenio Perdigão Fragoso Maria Carolina Elias

Replication Protein A (RPA), the major single stranded DNA binding protein in eukaryotes, is composed of three subunits and is a fundamental player in DNA metabolism, participating in replication, transcription, repair, and the DNA damage response. In human pathogenic trypanosomatids, only limited studies have been performed on RPA-1 from Leishmania. Here, we performed in silico, in vitro and i...

2014
Lysangela Ronalte Alves Camila Oliveira Patrícia Alves Mörking Rafael Luis Kessler Sharon Toledo Martins Bruno Accioly Alves Romagnoli Fabricio Kerrynton Marchini Samuel Goldenberg

Trypanosome gene expression is regulated almost exclusively at the posttranscriptional level, through mRNA stability, storage and degradation. Here, we characterize the ribonucleoprotein complex (mRNPs) corresponding to the zinc finger protein TcZC3H39 from T. cruzi comparing cells growing in normal conditions and under nutritional stress. The nutritional stress is a key step during T. cruzi di...

2016
Sébastien Brosson Frédéric Fontaine Marjorie Vermeersch David Perez-Morga Etienne Pays Sabrina Bousbata Didier Salmon

Trypanosoma cruzi is a protozoan parasite transmitted by a triatomine insect, and causing human Chagas disease in South America. This parasite undergoes a complex life cycle alternating between non-proliferative and dividing forms. Owing to their high energy requirement, replicative epimastigotes of the insect midgut display high endocytic activity. This activity is mainly restricted to the cyt...

Journal: :Journal of cell science 2001
A C Monteiro M Abrahamson A P Lima M A Vannier-Santos J Scharfstein

Lysosomal cysteine proteases from mammalian cells and plants are regulated by endogenous tight-binding inhibitors from the cystatin superfamily. The presence of cystatin-like inhibitors in lower eukaryotes such as protozoan parasites has not yet been demonstrated, although these cells express large quantities of cysteine proteases and may also count on endogenous inhibitors to regulate cellular...

Journal: :Infection and immunity 1993
F R Franco G S Paranhos-Bacallà L M Yamauchi N Yoshida J F da Silveira

We have cloned and sequenced a cDNA for a metacyclic trypomastigote-specific glycoprotein with a molecular mass of 90 kDa, termed MTS-gp90. By immunoblotting, antibodies to the MTS-gp90 recombinant protein reacted exclusively with a 90-kDa antigen of metacyclic trypomastigotes. The insert of the MTS-gp90 cDNA clone strongly hybridized with a single 3.0-kb mRNA of metacyclic forms, whereas the h...

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