It is still poorly understood how epileptiform events can recruit cortical circuits. Moreover, the speed of propagation of epileptiform discharges in vivo and in vitro can vary over several orders of magnitude (0.1-100 mm/s), a range difficult to explain by a single mechanism. We previously showed how epileptiform spread in neocortical slices is opposed by a powerful feedforward inhibition ahea...

introduction: the hippocampus was recognized as an important focus of epileptic seizures. a long-term potentiation (ltp) like that of epileptiform activities is considered as synaptic which has been observed for the first time in hippocampal formation. the purpose of the present study was investigating the synaptic plasticity induced by tetanic stimulation at ca1 area of the rat hippocampal sli...

The transition from brief bursts of synchronous population activity characteristic of interictal epileptiform discharges (IEDs) to more prolonged epochs of population activity characteristic of seizures (ictal-like activity) was recorded in juvenile rat hippocampal-entorhinal cortex slices and hippocampal slices using multiple-site extracellular electrodes. Epileptiform activity was elicited by...

Chlormethiazole has sedative, hypnotic, anticonvulsant and neuroprotective properties. Using in vitro grease-gap recordings, we show that it inhibits epileptiform activity in neocortical slices superfused with Mg(2+)-free medium (IC(50) approximately 200 microM). At an antiepileptic concentration (300 microM), chlormethiazole potentiated the action of exogenously applied GABA (1 mM) but did not...

We evaluate occurrence of seizure-like activity in computational network models based on the histology of mammalian cortex. In the simulations, seizure onset activity in a network (active patch) is connected to a larger patch of cells (passive patch). The following scenarios were investigated: (1) the activeand passive patches are contiguous with all connectivity intact; (2) active and passive ...

Biosignals are such signals that quantify the physiological processes of a living organism. Classification of biosignals aims at inferring the physiological condition of the organism based on the biosignals obtained from it. In this thesis, the classifications of two biosignals originating from the human body are studied in detail: the electroencephalogram (EEG) and acceleration signals recorde...