What is status epilepticus? For all the criticisms leveled at the now-traditional definition accepted by the International League Against Epilepsy (ILAE) and based on the 1962 Marseilles conference, “a condition characterized by an epileptic seizure which is so frequently repeated or so prolonged as to create a fixed and lasting epileptic condition” (1), this definition does capture the concept...

Epilepsy is a neurological disorder marked by sudden recurrent episodes of sensory disturbance, loss of consciousness, or convulsions, associated with abnormal electrical activity in the brain. The sudden and seemingly unpredictable nature of seizures is one of the most compromising aspects of the disease epilepsy. Most epilepsy patients only spend a marginal part of their time actually having ...

One of the problems solved by analyzing data long-term Video EEG monitoring is differentiation epileptic and artifact events. For this, not only multichannel signals are used, but also video analysis, since traditional methods based on analysis wavelet spectrograms cannot reliably distinguish an seizure from a chewing artifact. In this paper, we propose algorithm for detecting events joint leve...

Epileptic nystagmus is defined as a quick, repetitive jerky movement of the eyeball associated with seizure activity. In cases of epileptic nystagmus associated with ictal discharge from multiple brain areas, localization of the exact epileptogenic zone could be extremely difficult. In a nine-year-old patient with epileptic nystagmus and vertigo associated with bilateral temporal and frontal lo...

Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons. It has also been shown to acutely induce epileptic seizure behavior in freely moving rats. However, whether CTZ induced seizure rats could develop to have recurrent seizure still remains unknown...

It is difficult to perform ictal vs. interictal MEG localization studies. MEG recordings of epileptic seizures are rare and are often accompanied by patient movements. However, during routine MEG recordings of a presurgical patient with epilepsy, a complex partial seizure was recorded with a whole head neuromagnetometer (4D Neuroimaging Magnes WHS2500). During seizure, the patient opened his ey...

The primary aim of this work was: to evaluate the time course of serum prolactin (PRL) increase following repetitive seizures in epileptic patients with (Group II) and without (Group I) temporal ischemia. Epileptic patients were examined after 2 or 3 epileptic seizures in wakefulness with seizure-free intervals of 4 hours. Serum PRL levels was assessed within 3 hours of the last epileptic seizu...

Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activi...

It is difficult to perform ictal vs. interictal MEG localization studies. MEG recordings of epileptic seizures are rare and are often accompanied by patient movements. However, during routine MEG recordings of a presurgical patient with epilepsy, a complex partial seizure was recorded with a whole head neuromagnetometer (4D Neuroimaging Magnes WHS2500). During seizure, the patient opened his ey...

Using wavelet analysis we have detected the presence of chirps in seizure EEG signals recorded from kindled epileptic rats. Seizures were induced by electrical stimulation of the amygdala and the EEG signals recorded from the amygdala were analyzed using a continuous wavelet transform. A time–frequency representation of the wavelet power spectrum revealed that during seizure the EEG signal is c...