Phytochemical investigation of the aqueous extract of Pithecellobium clypearia afforded one novel compound, clypearoside A (1), and one new stereoisomer, (-)-(2S,3S)-epigallocatechin-7-gallate (2) and four known ones (3-6). Their structures were elucidated on the basis of spectroscopic data, especially 2D NMR, HRESIMS and ECD spectra. Compounds 2-4 showed strong activity against DPPH (diphenylp...

It has been reported that inhibition of fatty-acid synthase (FAS) is selectively cytotoxic to human cancer cells. Considerable interest has developed in identifying novel inhibitors of this enzyme complex. Our previous work showed that green tea (-)-epigallocatechin gallate can inhibit FAS in vitro. To elucidate the structure-activity relationship of the inhibitory effects of tea polyphenols, w...

The effects of pH (2.2–8.0) and temperature (25–100 °C) on the instrumental color a model beverage containing (−)-epigallocatechin-3-gallate (EGCG) were investigated. As increased, lightness (L*) decreased while redness yellowness (a* b*, respectively) increased. Using spectral scanning, it was possible to verify that changes might be related structural rearrangement EGCG aqueous solution in sy...

Inflammatory Breast Cancer (IBC) is a highly aggressive form of cancer characterized by high rates of proliferation, lymphangiogenesis and metastasis, and an overall poor survival. As regular green tea consumption has been associated with improved prognosis of breast cancer patients, including decreased risk of recurrence, here the effects of the green tea polyphenol epigallocatechin-3-gallate ...

Epigallocatechin-3-gallate (EGCG) is a type of catechin found in green tea. EGCG exhibits a variety of activities, including anti-inflammatory, antidiabetes, antiobesity, and antitumor. In this review, we focus on the antitumor effects of EGCG. EGCG inhibits carcinogen activity, tumorigenesis, proliferation, and angiogenesis, and induces cell death. These effects are associated with modulation ...