INTRODUCTION Chorioamnionitis is a risk factor for preterm delivery. Intrauterine infection leads to the fetal inflammatory response which is characterised by elevated cytokine levels. Chorioamnionitis is reported to cause accelerated but abnormal lung maturation, resulting in decreased incidence of respiratory distress syndrome (RDS) but increased chronic lung disease (CLD), and predisposes th...

The Enterobacter sakazakii is considered an emerging pathogen and has been recently connected to neonatal cases of necrotizing enterocolitis and meningitis due to use of contaminated powdered infant formula. However its presence is not limited to powdered infant formula; it can also be found in a broad range of foods and in water, in a variety of areas, including hospitals and houses. Due to th...

Development of necrotising enterocolitis (NEC) is considered to be dependent on the bacterial colonisation of the gut. With little concordance between published data and a recent study failing to detect a common strain in infants with NEC, more questions than answers are arising about our understanding of this complex disease.

Five cases of neonatal necrotising enterocolitis occurred in full-term infants at Kingston Hospital in the space of 15 months. In all cases only the colon was involved. The pathological findings are discussed particularly in relation to the aetiology of the disease.

OBJECTIVE To determine the effect of dual-strain probiotics on the development of necrotizing enterocolitis (NEC), mortality and nosocomial bloodstream infections (BSI) in preterm infants in German neonatal intensive care units (NICUs). DESIGN A multi-center interrupted time series analysis. SETTING 44 German NICUs with routine use of dual-strain probiotics on neonatal ward level. PATIENT...

During the 3 years 1972-74, 17 infants were treated for necrotizing enterocolitis (NEC) in the Neonatal Unit at University College Hospital. The incidence of the illness was 0 2% of live births in the hospital and 2.7% of those referred from elsewhere. The mean birthweight of the affected infants was 1832 g (range 878-3850 g) and mean gestational age 33 weeks (range 28-40 weeks). The illness wa...

Fetal malnutrition is an important risk factor for both early and late neonatal outcome and adult diseases. In this study, we aimed to investigate the incidence and characteristics of fetal malnutrition and its impacts on early neonatal morbidity and mortality in preterm infants by using the clinical assessment of nutritional status score (CANSCORE). Preterm infants whose gestational ages were ...

Preterm infants are susceptible to infection and necrotizing enterocolitis (NEC) and are often treated with antibiotics. Simultaneous administration of enteral and parenteral antibiotics during the first days after preterm birth prevents formula-induced NEC lesions in pigs, but it is unknown which administration route is most effective. We hypothesized that only enteral antibiotics suppress gut...

It is estimated that nearly 12% of infants born weighing less than 1500 g will develop NEC and about 30% of these infants will not survive. [4] More than 85% of all NEC cases occur in infants of very low birth weight or in very premature infants. [5]Full-term and nearterm infants also develop the disease. Patent ductus arteriosus is a risk factor in premature babies, especially if conservative ...

Introduction Necrotising enterocolitis (NEC) is a disease of the infant gastrointestinal tract (GIT) most commonly found in premature newborns. Although the aetiology and pathogenesis of the disease is not fully understood, in its most severe cases, NEC rapidly progresses from bacterial invasion of the intestinal wall to full-thickness bowel necrosis, leading to perforation and subsequent perit...