Ent-kaurene diterpenoids are the largest group of known Isodon diterpenoids. Among them, oridonin is accumulated in the leaves, and is the most frequently studied compound because of its antitumor and antibacterial activities. We have identified five copalyl diphosphate synthase (CPS) and six kaurene synthase-like (KSL) genes by transcriptome profiling of Isodon rubescens leaves. An in vitro as...

Objectives: The objectives of this study were to report on and evaluate the results of chiropractic treatment of patients referred from an ear, nose and throat (ENT) department with neck/jaw-related symptoms. Methods: The target group consisted of 46 consecutive patients who had experienced a long period of diversified symptoms relating to neck and jaw dysfunction. Clinical and neurological exa...

Bioassay-guided fractionation of hexane extracts of Gymnosperma glutinosum (Asteraceae) leaves, collected in North Mexico, afforded the known compounds hentriacontane (1) and (+)-13S,14R,15-trihydroxy-ent-labd-7-ene (2), as well as the new ent-labdane diterpene (-)-13S,14R,15-trihydroxy-7-oxo-ent-labd-8(9)-ene (3). In addition, D-glycero-D-galactoheptitol (4) was isolated from the methanolic ex...

GDANSK, Poland (A P) — Solidarity ch ief Lech W alesa re tu rned to a joyful hom ecom ing yesterday after m ysteriously disappearing for m ore than a day following his release from 11 m onths in martial-law custody. There was no im m ediate explana­ tion for Walesa’s delay in com ing hom e to the first-floor apartm ent in this Baltic port city w here his wife, seven children and hundreds of fri...

Inflammation is a fundamental pathophysiological process which occurs in the course of several diseases. The present work describes capacity phytoprostanes (PhytoPs) and phytofurans (PhytoFs) (plant oxylipins), plant-based foods, to modulate inflammatory processes mediated by prostaglandins (PGs, human oxylipins) lipopolysaccharide (LPS)-stimulated THP-1 monocytic cells, through panel 21 PGs PG...

In the title mol-ecule, C(16)H(17)ClF(2)N(3)O(2)P, the N-H unit of the C(=O)NHP(=O) fragment adopts a syn orientation with respect to the P=O group. The two F atoms and the Cl atom of the ClF(2)C group are disordered over two sets of sites with refined occupancies of 0.605 (6) and 0.395 (6). In the crystal, mol-ecules are linked via N-H⋯O=C hydrogen bonds the and the (N-H⋯)(N-H⋯)O=P group into ...

Gibberellins (GAs) are diterpenoid phytohormones that regulate various aspects of plant growth. Tetracyclic hydrocarbon ent-kaurene is a biosynthetic intermediate of GAs, and is converted from geranylgeranyl diphosphate, a common precursor of diterpenoids, via ent-copalyl diphosphate (ent-CDP) through successive cyclization reactions catalysed by two distinct diterpene synthases, ent-CDP syntha...

Zhi-Qiang Liu1,2 and Peng-Yuan Zheng1* 1Department of Gastroenterology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China 2Shenzhen Key Laboratory of Ear, Nose and Throat (ENT), Department of Rhinology, Institute of ENT, Longgang ENT Hospital, Shenzhen, Guangdong, China *Corresponding author: Peng-Yuan Zheng, Department of Gastroenterology, The Fifth Affiliat...