Hereditary hemorrhagic telangiectasia (HHT), or Osler-Rendu-Weber syndrome, is a heterogeneous inherited disorder characterized by multi-systemic vascular dysplasia and wide variation in its phenotypic expression. Hepatic manifestation is seen in about 8 to 30 % of the patients. The molecular basis for liver involvement is unknown. We screened the two known HHT disease loci, the ALK1 (ACVRL1) a...

Hereditary hemorrhagic telangiectasia (HHT) is an inherited disorder that is characterized by abnormal communication between the arteries and veins in the skin, mucosa, and various organs. HHT has been reported to show significant phenotypic variability and genetic heterogeneity with wide ethnic and geographic variations. Although mutations in the endoglin (ENG) and activin A receptor type II-l...

When functional neuromuscular stimulation (FNS) is used to restore the use of paralyzed limbs after a spinal cord injury or stroke, it may be possible to control the stimulation using feedback information relayed by natural sensors in the skin. In this study we tested the hypothesis that the force applied on glabrous skin can be extracted from the electroneurographic (ENG) signal recorded from ...

This paper presents the dynamic neural networks partial least squares (DNNPLS) as a strategy for open-loop identification of multivariable chemical processes that circumvent some of the difficulties associated with multivariable process control. The DNNPLS is an extension of the neural networks’ partial least squares (NNPLS) developed by Qin and McAvoy (Comp. Chem. Eng. 20 (1992) 379). Here, a ...

The problem of scheduling under bounded uncertainty is addressed. We propose a novel robust optimization methodology, which when applied to mixed-integer linear programming (MILP) problems produces “robust” solutions which are in a sense immune against bounded uncertainty. Both the coefficients in the objective function, the left-hand-side parameters and the right-hand-side parameters of the in...

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Journal: Artificial Intelligence for Engineering Design, Analysis and Manufacturing Manuscript ID: Draft Manuscript Type: Research Paper Date Submitted by the Author: n/a Complete List of Authors: Cunin, Maxime; University of Liège, Faculty of Engineering Sciences Yang, Maria; MIT, Mechanical Eng and Eng Systems Elsen, Catherine; University of Liège, Faculty of Engineering Sciences Keyword: Arc...

AB STRAC'T A multipolar split cuff electrode is used for fascicle selective recording of the electroneurogram (ENG) of the sciatic nerve of the rabbit. Several electrode configurations were evaluated with regarding to seleclivity: the peroneal and tibial nerves were stimulated alternately and the ENG was recorded at different sides of the sciatic nerve. The results for two electrode configurati...