نتایج جستجو برای: endotoxin tolerance
تعداد نتایج: 137850 فیلتر نتایج به سال:
Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity.
Sepsis remains a major cause of morbidity and mortality in hospitalized patients, with AKI serving as an ominous prognostic factor. According to the current literature, the pathogenesis of AKI-induced sepsis, albeit being poorly understood, is thought to be multifactorial.1 Consequently, therapeutic interventions to curtail deterioration in kidney function in the setting of sepsis have beenmost...
Sepsis mortality varies dramatically in individuals of variable immune conditions, with poorly defined mechanisms. This phenomenon complements the hypothesis that innate immunity may adopt rudimentary memory, as demonstrated in vitro with endotoxin priming and tolerance in cultured monocytes. However, previous in vivo studies only examined the protective effect of endotoxin tolerance in the con...
Interfering with the endotoxin-mediated cytokine cascade is thought to be a promising approach to prevent septic complications in gram-negative infections. The synthetic lipid A analog SDZ MRL 953 has been shown to be protective against endotoxic shock and bacterial infection in preclinical in vivo models. As part of a trial of unspecific immunostimulation in cancer patients, we conducted a dou...
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