background: the ultrastructural analysis of cultured follicles could direct us to understand subcellular changes during in vitro culture. objective: this study was done to verify the ultrastructural characteristics of in vitro cultured mouse isolated preantral follicles in co-culture system in the presence and absence of leukemia inhibitory factor (lif) materials and methods: mechanically isola...

Background: The prevalence of endometriosis in the general population is estimated at 7-10%. Endometriosis is one of the causes of primary and secondary infertility in 30% of women. There are various risk factors for this disease. The present study aimed to determine the association between sexual activity during menstruation and endometriosis. Materials and Methods: This case-control study rec...

BACKGROUND For the implantation of endometrium in ectopic locations, remodelling of the extracellular matrix (ECM) is necessary. Many studies have shown an increased expression of various proteases in the ectopic endometrium of women with endometriosis. Few, however, have addressed possible changes in protease expression in the eutopic endometrium. METHODS AND RESULTS Herein, we reveal an inc...

Here we analysed rare and acute complications of endometriosis in pregnant women by searching Cochrane, HINARY, PubMed databases. Keywords were “rare”, “causes”, “acute”, “complications”, “endometriosis”, “pregnancy”. The search depth was 10 years (2011−2021). In total, found 126 publications, 41 which met the selection criteria. course pregnancy childbirth patients with is insufficiently studi...

Background: Macrophage migration inhibitory factor (MIF) is a key pro-inflammatory cytokine that is secreted by accumulated active macrophages in ectopic tissue of endometriosis. MIF is involved in pathophysiological events of endometriosis, such as angiogenesis and cell proliferation. MIF that stimulates the synthesis of PGE2, leads to over-expression of local estradiol synthesis in endometrio...

Introduction: Endometriosis is the presence of endometrial glandular and stromal cells outside of the uterine cavity. This disease is found in about 10% of women of the reproductive age and in up to 50% of women with infertility. Surgery continues as the first-line treatment to eradicate endometriotic lesions but recurrence of the condition occurs in up to 47% of women. Materials and Methods: T...

Background: Endometriosis is a complex disease that profoundly affects the quality of life in many women. This disease affects roughly one in ten women of reproductive age. Endometriosis induces a variable amount of inflammatory reaction in pelvic environment. An active immune system needs to recognize these inflammatory agents. Rapid innate immune system defenses against infections involve the...