Acromegaly is a rare and chronic disease, most often caused by a pituitary adenoma. Excessive secretion of the growth hormone (GH) leads to hepatic secretion of insulin-like growth factor-1 (IGF-1), which in turn causes characteristic changes in the patient's appearance, many skeletal deformities and metabolic disorders. In addition to somatic symptoms, acromegalic patients demonstrate psychoso...

Hyperparathyroidism is a frequent endocrinopathy, often diagnosed at the stage of subclinical hypercalcemia by systematic calcium measurement and advent new parathyroid hormone techniques. Brown tumors represent late-onset, locally aggressive but potentially benign non-metastatic bone complication secondary to an abnormality metabolism within context hyperparathyroidism. It usually late complic...

Poly Cystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, resulting from insulin resistance and compensatory hyperinsulinemia. This results adverse effect on multiple organ systems may result alteration serum lipids, anovulation, abnormal uterine bleeding infertility. According to Ayurvedic view PCOS can be correlated with Aarthava Kshaya. It was reveal...

Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its benefit in long-term use is not well established. A 55-year-old man with POEMS and debilitating po...

INTRODUCTION Renal involvement in POEMS (polyneuropathy, organomegaly, endocrinopathy, M-band, skin changes) syndrome is considered to be an under-diagnosed phenomenon with no clear treatment path. The limited literature suggests steroids to be the drug of choice, although improvements are limited and usually reverse on withdrawal of the drug. CASE PRESENTATION A 52-year-old Caucasian woman p...

The authors report a case of sensorimotor polyneuropathy, diffuse cutaneous hyperpigmentation, skin sclerodermiform thickening and papular lesions in the infraclavicular and abdominal region. Besides weight loss, there were diabetes mellitus and hypothyroidism. The alterations were consistent with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes) syndr...