نتایج جستجو برای: endocrine cells

تعداد نتایج: 1419076  

Journal: :The American journal of physiology 1999
S T Willard M D Amstutz E J Abraham J P Castaño D C Leaumont W J Faught L S Frawley

Dynamic intracellular processes in endocrine cells are usually controlled by the coordinated modulation of two or more functionally related genes. Attempts to gain a more complete understanding of these processes would be facilitated greatly by a method enabling activity measurements of two genes at the same time. Here we describe how we developed such a system and used it to determine indirect...

2012
Rajesh Pareta John P. McQuilling Alan C. Farney Emmanuel C. Opara

The pancreas is a dual-function organ featuring both endocrine and exocrine tissue. Endocrine functionality is provided by approximately one million cell clusters called the islets of Langerhans. Islets consist of four main cell types, 1) ┙ cells: secrete glucagon (increases glucose in blood); ┚ cells: secrete insulin (decreases glucose in blood); ├ cells: secrete somatostatin (regulates ┙ and ...

Journal: :Endocrinology 1993
G Lahr A Mayerhofer S Bucher D Barthels W Wille M Gratzl

The adhesive properties of neural cell adhesion molecules (NCAMs) can be modified by alternative splicing of the primary transcript or posttranslational modifications. In the present study, we describe distinct forms of alternative splicing and posttranslational modification of the extracellular domain of NCAM of various endocrine tissues and derived tumor cells of the rat. Using an antiserum d...

Journal: :iranian journal of veterinary research 2006
m. ebrahimi

there are increasing evidences that show many xenobiotic chemicals (called as endocrine disruptorchemicals edcs) through interfering with endocrine system, have the capability to induce developmentaland reproductive abnormalities in humans and animals. the yolk protein precursor vitellogenin (vtg) hasproved to be a simple and sensitive biomarker for assessing exposure of fish to edcs especially...

2015
Kazuhiro Ikeda Kuniko Horie-Inoue Toshihide Ueno Takashi Suzuki Wataru Sato Takashi Shigekawa Akihiko Osaki Toshiaki Saeki Eugene Berezikov Hiroyuki Mano Satoshi Inoue

Breast cancer is a hormone-dependent cancer and usually treated with endocrine therapy using aromatase inhibitors or anti-estrogens such as tamoxifen. A majority of breast cancer, however, will often fail to respond to endocrine therapy. In the present study, we explored miRNAs associated with endocrine therapy resistance in breast cancer. High-throughput miRNA sequencing was performed using RN...

Journal: :Development 1998
F Miralles P Czernichow R Scharfmann

In this study, we have investigated the role of the embryonic mesenchyme in the development of the pancreas. We have compared the development in vitro of E12.5 rat pancreatic rudiments grown in the presence or absence of mesenchyme. When the E12.5 pancreatic epithelial rudiment is cultured in the presence of its surrounding mesenchyme, both morphogenesis and cytodifferentiation of the exocrine ...

2018
Sei Saitoh Nobuhiko Ohno Yurika Saitoh Nobuo Terada Satoshi Shimo Kaoru Aida Hideki Fujii Tetsuro Kobayashi Shinichi Ohno

Combined analysis of immunostaining for various biological molecules coupled with investigations of ultrastructural features of individual cells is a powerful approach for studies of cellular functions in normal and pathological conditions. However, weak antigenicity of tissues fixed by conventional methods poses a problem for immunoassays. This study introduces a method of correlative light an...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Alexandra F Leary Suzanne Drury Simone Detre Sunil Pancholi Anne E Lykkesfeldt Lesley-Ann Martin Mitch Dowsett Stephen R D Johnston

PURPOSE Acquired endocrine resistance in estrogen receptor (ER)alpha+/human epidermal growth factor receptor 2-negative (HER2-) breast cancer has been associated with modest adaptive increases in HER2, although exactly how aberrant HER2 signaling affects the ERalpha pathway is poorly understood. We investigated (a) whether the epidermal growth factor receptor/HER2 inhibitor lapatinib could rest...

Journal: :Arquivos brasileiros de endocrinologia e metabologia 2010
Ana Luiza R Rolim Susan C Lindsey Ilda S Kunii Aline M Fujikawa Fernando A Soares Maria Izabel Chiamolera Rui M B Maciel Magnus R Dias da Silva

Ion channels serve diverse cellular functions, mainly in cell signal transduction. In endocrine cells, these channels play a major role in hormonal secretion, Ca(2+)-mediated cell signaling, transepithelial transport, cell motility and growth, volume regulation and cellular ionic content and acidification of lysosomal compartments. Ion channel dysfunction can cause endocrine disorders or endocr...

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