نتایج جستجو برای: endochondral bone
تعداد نتایج: 305621 فیلتر نتایج به سال:
In protein folding and secretion disorders, activation of endoplasmic reticulum (ER) stress signaling (ERSS) protects cells, alleviating stress that would otherwise trigger apoptosis. Whether the stress-surviving cells resume normal function is not known. We studied the in vivo impact of ER stress in terminally differentiating hypertrophic chondrocytes (HCs) during endochondral bone formation. ...
The newly evolved field of regenerative medicine is offering solutions in the treatment of bone or cartilage loss and deficiency. Mesenchymal stem cells, as well as articular chondrocytes, are potential cells for the generation of bone or cartilage. The natural mechanism of bone formation is that of endochondral ossification, regulated, among other factors, through the hormones dexamethasone an...
In the long bones, endochondral bone formation proceeds via the development of a diaphyseal primary ossification centre (POC) and an epiphyseal secondary ossification centre (SOC). The growth plate, the essential structure for longitudinal bone growth, is located between these two sites of ossification. Basically, endochondral bone development depends upon neovascularization, and the early gene...
Collagen XI alpha 1 (Col11a1) is an extracellular matrix molecule required for embryonic development with a role in both nucleating the formation of fibrils and regulating the diameter of heterotypic fibrils during collagen fibrillar assembly. Although found in many different tissues throughout the vertebrate body, Col11a1 plays an essential role in endochondral ossification. To further underst...
Endochondral ossification occurs when chondrocytes proliferate, differentiate, hypertrophy and eventually undergo apoptosis. Multiple systemic and local stimuli orchestrate to regulate this process, among which estrogen is one key factor. Estrogen induces the pubertal growth spurt, but later causes epiphyseal fusion terminating the endochondral ossification process. The effect of estrogen on en...
The digit tips of children and rodents are known to regenerate following amputation. The skeletal structure that regenerates is the distal region of the terminal phalangeal bone that is associated with the nail organ. The terminal phalanx forms late in gestation by endochondral ossification and continues to elongate until sexual maturity (8 weeks of age). Postnatal elongation at its distal end ...
Bone represents a well vascularized structure which is remodelled and renewed continuously. It consists of osteoblasts, osteoclasts osteocytes have precise role in the context endochondral intramembranous ossification. While link between bone tissue, marrow haematopoiesis crucial for generation progenitor forming cells, recent research indicates that physiology as healing, repair regeneration d...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید