Piper nigrum (black pepper) is used in Indian traditional medicine and its main alkaloid, Piperine (PIP), presents antioxidant, antitumor neuroprotective pharmacological properties. This substance insoluble aqueous media can irritate the gastrointestinal tract. Aiming to avoid these inconvenient characteristics enable PIP oral administration, this study suggested microencapsulation through emul...

In this work, polyvinylchloride (PVC) membrane prepared via casting solution technique and phase inversion method. N, N dimethylacetamide (DMAC) was used as primary solvent and Tetrahydrofuran (THF) was used as a co-solvent. The effects of parameters such as membrane thickness, evaporation time of casting film before immersion precipitation and addition of polyethylenglchol (PEG) on PVC membran...

INTRODUCTION Developing strategies for the delivery of hydrophilic drugs and macro molecules such as proteins and peptides is emerging as an important in research field as several new synthesized molecules are hydrophilic in nature. Some of the major problem incurred by the small hydrophilic molecules is low encapsulation, low permeability across barriers, shorter half-life in the circulatory s...

conclusions according to release exponent n > 1, diffusion mechanism is super case п. the prepared micronized benzoyl peroxide in foamable formulation was stable according to different pharmaceutical evaluation. the emu oil incorporated in this formulation could reduce drawback of bpo (benzoyl peroxide). this formulation could be a good candidate in acne treatment. objectives benzoyl peroxide f...

objective(s) the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. materials and methods microspheres were prepared by water-in-oil-in-oil (w/o1/o2) emulsion-solvent diffusion (esd). a mixed solvent system consisting of acetonitrile and dichloromethane ...