introduction: in single photon emission computed tomography (spect), the projection data used for image reconstruction are distorted by several factors, including attenuation and scattering of gamma rays, collimator structure, data acquisition method, organ motion, and washout of radiopharmaceuticals. all these make reconstruction of a quantitative spect image very difficult. simulation of a sp...

Microvascular abnormalities of the coronary circulation are present in several cardiac disorders, are associated with risk factors, and may be present in systemic disease. For the diagnosis and quantification of microvascular dysfunction, non invasive imaging techniques can be used. This paper will highlight the roles of exercise ECG, single photon emission computed tomography, echocardiography...

In this paper, we extend a nonnegatively constrained iterative method and three stopping rules for its iterations to the medical imaging inverse problems of computed tomography (CT), positron emission tomography (PET), and single photon emission computed tomography (SPECT); the iterative method and stopping rules were introduced for use in astronomical imaging. The paper begins with a brief int...

Noninvasive assessment of myocardial perfusion is important in the diagnosis and risk stratification of patients with known or suspected coronary artery disease (CAD). Although single-photon emission computed tomography (SPECT) is most commonly used, multiple modalities including myocardial contrast echocardiography (MCE), positron emission tomography (PET), cardiac MRI (CMR), and cardiac compu...

Quantitative software for the analysis and review of myocardial perfusion emission computed tomography images is an indispensable tool in the nuclear physician's evaluation of patients with known or suspected heart disease. The Corridor4DM (4DM) application (formerly known as 4DM-SPECT), developed at the University of Michigan Medical Center, is a quantitative software application providing aut...