Recent studies have demonstrated that the central dopaminergic system is implicated in the mechanism underlying general anesthesia. Here, we investigated whether dopaminergic ventral tegmental area (VTA) neurons participate in general anesthesia. Dopaminergic VTA neurons were selectively ablated from male Sprague Dawley rats via the bilateral infusion of 6-hydroxydopamine (6-OHDA) into the VTA....

Emergence agitation preventive medicine should be combined with pediatric anesthesia because of the high frequency of emergence agitation. However, it is challenging to determine the most appropriate medication that can be introduced into pediatric anesthesia for the sake of emergence agitation prevention. We reviewed and retrieved the data from PubMed and Embase. Various medications were asses...

BACKGROUND Desflurane with a laryngeal mask airway may have advantages during ambulatory anesthesia. However, desflurane-induced airway irritability makes the use of desflurane challenging, especially in children. This study compared desflurane with sevoflurane maintenance anesthesia in terms of respiratory events and the emergence characteristics in children with a laryngeal mask airway. MET...

THEORIES of general anesthetic mechanism have evolved from the unitary hypothesis of Claude Bernard in the nineteenth century to our current understanding of the multiple receptors and neural systems affected by anesthetic agents. As the scientific study of general anesthesia has progressed, it has become clear that early unifying theories of anesthetic mechanism, although elegant, do not accou...

PURPOSE To investigate the effects of two different inhalation anesthetic expelling methods on emergence agitation in infants following sevoflurane anesthesia. METHODS 100 infants (1~3 years old) with cleft lip and palate and ASA classification I~II were randomized into two groups, a sevoflurane concentration decreasing expelling group (group n = 50 cases) and a low fresh gas flow expelling g...

a 25-yr-old iranian woman with incomplete abortion who was diagnosed and scheduled for dilatation and curettage procedures under general anesthesia. after premedication with fentanyl 50µg and midazolam 2mg and enough pre-oxygenation, anesthesia was induced by sodium thiopental 250 mg and succynilcholine 60 mg with mask ventilation. after completion of procedure, the patient had a period of lary...

results in the i-gel group, the success rate was 66.7% for placement on the first attempt, 16.7% for the second, and 3.33% for the third attempt. in the lma group, the success rates were 80.6% and 12.9% for the first and second attempts, respectively. failure in placement occurred in four cases in the i-gel and two cases in lma groups. the mean insertion time was not significantly different bet...

this experimental study was done in order to determine the effect of pentozocin to antagonise respiratory   depression due to fentanyle during general anesthesia in selected hospitals of the medical science university of iran and tehran.   subjects of this study consisted of 50 patients who were chosen randomly, and divided into two group of 25   each. group one received pentazocine before the ...