Rhabdomyosarcomas of the parotid and submandibular glands have the histological appearance of a skeletal muscle tumor yet can be found in tissue with no striated muscular elements. We examine the potential cell-of-origin for rhabdomyosarcoma and whether salivary tumors represent primary malignancy or metastasis. We have previously established genetically engineered mouse models of rhabdomyosarc...

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood. The neoplasm probably originates from pluripotential mesenchyme, and may occur anywhere in the body. Thirty to 40% arise in the head and neck. Imaging studies typically show a homogeneous soft-tissue mass, often with poorly defined margins and permeative bone destruction (1-5). We report an unusual case of embryonal RMS...

Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children. The aim of study was to retrospectively review the treatment results of childhood rhabdomyosarcoma and identify prognostic factors. 60 children with rhabdomyosarcoma treated between 1996 and 2002 in Shafa Hospital were reviewed. The data were analyzed for clinico-epidemiological factors. Age, gender, race, histology ty...

Costello syndrome is caused by heterozygous de novo missense mutations in the protooncogene HRAS with tumor predisposition, especially rhabdomyosarcoma. We here report two pediatric patients with Costello syndrome and umbilical ligament rhabdomyosarcoma. A review of the literature published in English in MEDLINE from January 1971 to June 2016 using the search terms "Costello syndrome" and "rhab...

abstract background: rhabdomyosarcoma is the most common soft tissue sarcoma among children which has two major subtypes: embryonal rhabdomyosarcoma (erms) and alveolar rhabdomyosarcoma (arms). distinction between these subtypes is mandatory to choose proper treatment and to determine prognosis. histopathologic study is the main method, but nowadays molecular studies like pcr are also used. the...

Endometriosis is ectopic presence of endometrial glands surrounded by endometrial stroma. Polypoidal endometriosis is a recently described entity which mimics neoplastic growth. Grossly and microscopically, polypoidal endometriosis can mimic benign and malignant tumors like adenofibroma, adenomyoma, low-grade stromal sarcoma, endometrial carcinoma and adenosarcoma. We report this case of polypo...

Embryonal rhabdomyosarcoma (ERMS) of biliary tree is a rare type of mesenchymal neoplasm diagnosed at surgery or by preoperative liver biopsy. We present a one year eight months old child who mimicked a choledochal cyst and was eventually treated with surgery, chemotherapy with IRS IV protocol and adjuvant postoperative radiotherapy to surgical bed with 6 MV photons to a dose of 5040 cGy in 28 ...

Fetal rhabdomyoma is not generally considered part of nevoid basal cell carcinoma syndrome. However, a review of the literature revealed five patients with this syndrome who also had fetal rhabdomyomas in various locations. We report the first patient with nevoid basal cell carcinoma syndrome and a fetal rhabdomyoma of the tongue. We recommend that embryonal rhabdomyosarcoma be ruled out to avo...

Two cases of primary malignant cardiac neoplasms are presented. The first, an angiosarcoma of the right atrium, developed in a 44-year-old housewife, who survived 23 days from the time of presentation; diagnosis was made at necropsy. The second, an embryonal rhabdomyosarcoma of the right ventricle, developed in a 17-year-old student; diagnosis was made by angiocardiography. He underwent surgery...