Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assor...

One of the potential advantages of high-voltage electron microscopes is that their greater penetrating power allows the use of thick sections (0.22 lt) to study three-dimensional cytoarchitecture . So far, this advantage has been limited because conventional methods of staining only allow the penetration of heavy metal solutions into sections to a depth of a few hundred Angstroms . For example,...

Transformačné vloženie lokálnych sietí do nadradenej siete Transformačné spojenie lokálnych geodetických sietí s nadradenou sieťou (napr. ŠTS v S-JTSK) nedáva jednoznačné výsledky. V závislosti od použitých transformačných faktorov vznikajú na homologických bodoch súradnicové rozpory, ktoré treba dodatočne zohľadniť pri výpočtoch transformovaných súradníc. Jednou z najvhodnejších transformačnýc...

A numerical model was developed to simulate the response of two instrumented, centrifuge model tests on soft clay and to investigate the factors that affect the seismic ground response. The centrifuge tests simulated the behavior of a rectangular building on 30 m uniform and layered soft soils. Each test model was subjected to several earthquakelike shaking events at a centrifugal acceleration ...

Proper estimation of foundation settlement is a crucial factor in designing shallow foundations. Recent literature shows the applicability of Artificial Neural Networks (ANNs) in predicting the settlement of shallow foundations. However, conventional ANNs have some drawbacks: getting trapped in local minima and a slow rate of learning. Utilization of an optimization algorithm such as Particle S...

Recent studies have shown what indispensable role mobile phones play as means of mobilization in contentious politics around the world. Nevertheless, there has been no clear elaboration of how mobile phone uses translate into mobilization in contentious politics. To fill this gap, the current study employs Passy’s (2003) framework of the threefold function of social ties as channels of mobiliza...

1. Introductory remarks .......................................................................................................................................... 2 2. The new "asymmetric competition" between open source networks and conventional bureaucratic organizations ..............................................................................................................................

Pile foundations for offshore wind turbines are subjected to large lateral loads. By mounting wings on the perimeter of regular monopiles, winged monopiles have shown better performance in resisting deformation under horizontal loading. However, hazardous effect local scour bearing capacity installed sandy seabed has not been systematically evaluated. In this study, a modified Mohr–Coulomb mode...

Abstract The scale effects on the global structural response of fibre-reinforced concrete (FRC) beams subjected to bending are discussed in framework Fracture Mechanics by means Updated Bridged Crack Model (UBCM). This model predicts different post-cracking regimes depending two dimensionless numbers: reinforcement brittleness number , N P which is related fibre volume fraction, V f ; and pull-...