BACKGROUND Available models for designing the structure of specific simulation-based learning (SBL) activities need further analysis. METHOD This retrospective study was conducted using independent samples t tests to examine differences in mean clinical nursing judgment development scores between students who completed a nursing program prior to the introduction of an experiential learning th...

BACKGROUND Simulation-based learning is a common educational tool in health care training and frequently involves instructional designs based on Experiential Learning Theory (ELT). However, little research explores the effectiveness and efficiency of different instructional design methodologies appropriate for simulations. The aim of this study was to compare 2 instructional design models, ELT ...

Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of the mammalian cancer-associated stem cell regulators RUNX and CBFβ, respectively) are known rate-limiting regulators of seam cell proliferation. He...

Gene regulation during development is an important biological activity that leads to synthesis of biomolecules at specific locations and specific times. The single tropomyosin gene of Caenorhabditis elegans, tmy-1/lev-11, produces four isoforms of protein: two from the external promoter and two from the internal promoter. We investigated the internal promoter of tropomyosin to identify sequence...

Cis-regulatory elements (CREs) are crucial links in developmental gene regulatory networks, but in many cases, it can be difficult to discern whether similar CREs are functionally equivalent. We found that despite similar conservation and binding capability to upstream activators, different GATA cis-regulatory motifs within the promoter of the C. elegans endoderm regulator elt-2 play distinctiv...

Erlotinib (ELT) as a small molecule with poor solubility, poor bioavailability, and instability in gastrointestinal environment, has been considered as a therapeutic agent for Non-Small-Cell Lung Cancer (NSCLC) therapy through oral administration. In the present study, ELT-liposome and ELT-NLCs were successfully prepared and characterized by assessment of the particle size, zeta potential (ZP),...

Introduction: Endovenous laser treatment (ELT) is a new treatment method for the reflux of the great saphenous vein. A successful ELT is dependent on the selection of optimum parameters required to achieve optimal vein damage while avoiding side effects including skin burns. The mathematical modeling of ELT can be used to understand the process of ELT. This study was conducted to examine the ef...


 Learning a foreign language implies lot more than learning grammar and vocabulary. Language learners should also acquire the necessary social cultural skills that would allow them to interact within context where target is expected be used. As result, EFL teachers face challenge of selecting explaining contents their students could employ when communicating with other English speakers. E...