Cholinesterases (ChEs) are classified as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) according to their substrate specificity and sensitivity to selected inhibitors. The activities of AChE in red blood cells (RBC-AChE) and BChE in serum can be used as potential biomarkers of suppressed and/or heightened activity in the central and peripheral nervous systems. Exposure to organop...

ezetimide belongs to a class of lipid lowering compounds that selectively inhibits intestinal absorption of cholesterol and related phytosterols. the purpose of this study is to establish a reliable and quick method for the assignment of ezetimibe in tablets form by high performance liquid chromatography with ultraviolet detection (hplc-uv). a rapid and sensitive hplc method has been developed ...

tolterodine tartrate, is a new, potent and competitive muscarinic receptor antagonist in clinical development for the treatment of urge incontinence and other symptoms of unstable bladder. the purpose of this study is to establish a reliable and quick method for the assignment of tolterodine tartrate by high performance liquid chromatography with ultraviolet detection (hplc-uv). a rapid and sen...

glutathione s-transferases (gsts) are widespread in fasciola. hepatica parasite and sheep liver tissue. study of gsts inhibition assays in f. hepatica and sheep liver tissue are a priority of chemotherapeutic targets in parasitic liver diseases including human fascioliasis in iran. in this research, the whole extract of f. hepatica and sheep liver tissues were purified and eluted for sodium dod...

serum ferritin (sf) levels in 734 seven-year-old children was measured by a radioimmuno assay method, and its possible relation-ship with hemoglobin, hematocrit and mchc was investigated. the results showed there was positive correlation between sf with hemo-globin, hematocrit and mchc values.

proteases play a key role in protein digestion in ticks and other haematophagous insects. our understanding of blood meal digestion in digestive system of ticks can be very useful for better understanding of basic rules for control of ticks. cells of the midgut endocytose blood components. blood proteins uptake by midgut cells, suggesting the presence of proteases in the midgut cells. in this s...

background and objective: changes of the enzyme acetylcholinesterase are involved in pathogenesis of different nervous disorders including alzheimer’s disease. this research work was conducted to evaluate the inhibitory effect of pistacia lentiscus ethanolic extract on acetylcholinesterase activity. materials and methods: activity of the enzyme acetylcholinesterase (ache) was measured by ellman...

Objective(s): Alzheimer’s disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of n...

patients with alzheimer's disease have cognitive deficits, impaired long-term potentiation and learning and memory. a progressive reduction in cholinergic neurons in some areas of the brain such as cortex and hippocampus is related to the deficits in memory and cognitive function in alzheimer’s disease (ad). in the current project a new series of phthalimide derivatives were synthesized. p...

many biological factors affect radiosensitivity. in this study, radiosensitivity among the different blood groups was investigated. peripheral blood sample of 95 healthy people were divided into two parts. one part was irradiated with 2 gy co-60 gamma rays and the second one was considered as control. then all the samples were studied by cytokinesis-blocked micronucleus assay (cbmn assay). our ...