In this study, the feasibility of conducting in silico experiments in near-realtime with anatomically realistic, biophysically detailed models of human cardiac electrophysiology is demonstrated using a current national high-performance computing facility. The required performance is achieved by integrating and optimizing load balancing and parallel I/O, which lead to strongly scalable simulatio...

the purpose of this experimental study was to evaluate the effect of chicken amniotic fluid (af) on a cross section of rat sciatic nerves. thirty adult male sprague-dawley rats weighing 275 to 300 g, were randomized into three groups treated with (1) amniotic fluid or af (n=10), (2) normal saline or ns (n=10), and (3) sham surgery (n=10). the af was aspirated from the amniotic cavity of incubat...

BACKGROUND Pediatric patients with persistent arrhythmias may require mechanical cardiopulmonary support. We sought to classify the population, spectrum, and success of current treatment strategies. METHODS AND RESULTS A multicenter retrospective chart review was undertaken at 11 sites. Inclusion criteria were (1) patients <21 years, (2) initiation of mechanical support for a primary diagnosi...

CARDIAC ELECTROPHYSIOLOGY CLINICS www.cardiacEP.theclinics.com Consulting Editor RANJAN K. THAKUR ANDREA NATALE September 2021 • Volume 13 Number 3

In order to investigate the pattern of wave propagation on atria in both sinus rhythm and arrhythmia, we constructed a computational model based on real anatomy. The original anatomic data which encompasses morphological and geometrical knowledge was created from a whole-body set of 2 mm interval magnetic resonance imaging (MRI) images of a male volunteer and represented in stl format. The anat...

Metabolic dysfunction in the relay nuclei of the rat vibrissa circuit follows traumatic brain injury (TBI). This study examined the effects of mild (1.4-1.5 atm) parasagittal fluid-percussion injury on the electrophysiology of this circuit. TBI caused significant reductions in slope and increases in latency of vibrissa-evoked field potentials 3 days after injury. Assessment of open-field swimmi...

For more than a century, Dutch scientists and clinicians have contributed importantly to the understanding of cardiac electrophysiology and to the diagnosis and treatment of cardiac rhythm disturbances. The first example supporting this statement that comes to mind is the development of a string galvanometer and the registration of the human electrocardiogram by Willem Einthoven in 1901 [1]. Al...

An 18 year old man with an incessant monomorphic VT was referred to the electrophysiology service for arrhythmia associated with decreased left ventricular ejection fraction (LVEF). The patient complained of occasional palpitations and was in functional class I. The past history was not significant and physical examination was unremarkable. The electrocardiogram showed wide QRS tachycardia sugg...

From the ICE CHIP Study Participating Institutions 1 Electrophysiology Research Foundation, Warren, NJ 2 Division of Cardiology, Aurora Health Care, Milwaukee, WI 3 Heart Centre Rotterdam, Erasmus University, Rotterdam ,The Netherlands 4 Section of Electrophysiology, Mayo Clinic, Jacksonville, FL 5 Center for Advanced Medicine, Department of Cardiology, Univ of Chicago, Chicago, IL 6 Department...

Electrophysiology study (EPS) and radiofrequency catheter ablation (RFCA) are widely used for the diagnosis and treatment of cardiac arrhythmias. EPS and RFCA are very complicated procedures, requiring extended periods of time and advanced technologies that vary according to the disease of the patients. Fluoroscopy is used during EPS and RFCA to guide the catheter through the vessels while view...