نتایج جستجو برای: electrophoretic mobility shift assay

تعداد نتایج: 446161  

Journal: :Molecular and cellular biology 1988
E L Mather

DNA-binding proteins that interact with the 3' end of the mouse mu immunoglobulin heavy chain gene were identified by the electrophoretic mobility shift assay. Complexes of distinctly different mobilities were formed by extracts prepared from B lymphoid lines representing different stages of maturation. The apparent stage-specific differences are shown to be due to proteolytic events that occur...

2001
Akira Maehara Tsuneo Yamane Seiichi Taguchi Yoshiharu Doi

Phasins (PhaP) are polyhydroxyalkanoate (PHA) granule-associated proteins that positively affect the PHA synthesis. In the heterologous expression experiment in Escherichia coli, introduction of only phaP caused overproduction of PhaP, and apparent repression of PhaP production was observed in the presence of phaR, which is located in the downstream region of phaP. It indicates that PhaR seems ...

2002
Tinghuai Wu Yueguo Chen Samuel K. S. Chiang Mark O. M. Tso

METHODS. Mice were exposed to intense green light. Lightinduced activation of NFB and its nuclear localization were studied by immunohistochemistry. The NFB DNA–binding activity in the retinas after exposure to light was measured by electrophoretic mobility shift assay (EMSA). Nuclear transactivation of NFB in the photoreceptor cells was determined by quantitative real-time (qRT)-PCR. The amoun...

2004
Hyun-Kyung Kim

Jun/Fos, a crucial factor in transmitting the tumor-promoting signal from the extracellular environment to the nuclear transcription machinery, has a dimerization interface possessing several coiled structural properties. Jun and Fos can interact with the DNA regulatory region, AP-1 (Activator Protein-1), which is composed of 5'-TGAC/GTCA-3'. Curcumin is a well-known anticancer and anti-inflamm...

2012
Julien Boulon

We evaluated 11 air ion spectrometers from Airel Ltd. after they had spent one year in field measurements as a part of the EUCAARI project: 5 Air Ion Spectrometers (AIS), 5 Neutral cluster and Air Ion Spectrometers (NAIS) and one Airborne NAIS (ANAIS). This is the first time that an ANAIS is evaluated and compared so extensively. The ion spectrometers’ mobility and concentration accuracy was ev...

2002
Heiko Kuhn Ekaterina Protozanova Vadim V. Demidov

We demonstrate that the gel electrophoretic mobility-shift assay (EMSA) can be used for site-selective and quantitative monitoring of nicks in linear double-stranded DNA (dsDNA) thus allowing to expediently follow the nicking activity of enzymes or other agents targeted to a designated dsDNA site. At elevated temperature and/or in the presence of urea, DNA fragments carrying a single nick produ...

Journal: :Mutagenesis 2001
W Frieauff A Hartmann W Suter

In recent years the Comet assay (or single cell gel electrophoresis assay) has been established as a rapid and sensitive method for the detection of DNA damage. For early genotoxicity screening of new chemical entities in industrial toxicology, the Comet assay is more and more used for assessment of the DNA damaging potential of a test compound. In order to increase compound screening throughpu...

Journal: :Revue scientifique et technique 2011
J McGiven A Taylor L Duncombe R Sayers D Albert M Banai J M Blasco S Elena D Fretin B Garin-Bastuji F Melzer P M Muñoz K Nielsen A Nicola M Scacchia M Tittarelli I Travassos Dias K Walravens J Stack

The World Organisation for Animal Health (OIE) requested an International Standard anti-Brucella melitensis Serum (ISaBmS) to standardise diagnostic tests and reagents for sheep and goats. The agreed criteria were the highest dilution (in negative serum) of the standard which must give a positive result and the lowest dilution (in negative serum) which must simultaneously give a negative result...

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