The periumbilical perforating pseudoxanthoma elasticum or perforating calcific elastosis is a rare disorder and its pathogenesis is associated with the alteration of elastic fibers, which may probably result from trauma. We present the case of a 70-year-old woman with long-time blackish maculas and keratotic surface papules on the periareolar and periumbilical regions. The histopathological exa...

Abstract People in the developed countries are living longer. Geriatric dermatology is playing an increasingly important role as chances of developing skin-related problems increase with their ageing. Skin ageing induced by two main processes: intrinsic and extrinsic. Extrinsic caused environmental factors such sun exposure, smoking, alcohol consumption, air pollution, poor nutrition. Intrinsic...

Sir, Patients with Down syndrome have increased prevalence of common dermatological conditions like folliculitis, atopy and vitiligo, besides having increased incidence of peculiar dermatoses like syringomas, milia-like calcinosis, acanthosis nigricans and elastosis perforans serpiginosa. The frequency of alopecia areata is also reported to be higher in Down syndrome Figure 1: Alopecia universa...

Exposure of the skin to ultraviolet (UV) radiation, particularly its UV-B component (280-320 nm), from the sun results in erythema, edema, hyperplasia, hyperpigmentation, sunburn cells, immunosuppression, photoaging, and skin cancer. Amongst these various adverse effects of UV-B radiation, skin cancer and photoaging are of great concern. More recent changes in lifestyle have led to a significan...

It is widely accepted that elastotic changes of the skin are primarily an indicator of cumulative sun exposure of the dermis and are a characteristic finding of actinic keratoses. To date, there have been few reports that measure the amount of elastic tissue objectively and quantitatively, especially in actinic keratoses. The computerized image analysis method has proved useful recently in dete...

APD: acquired perforating dermatosis CRF: chronic renal failure DM: diabetes mellitus EPS: elastosis perforans serpiginosa ESRD: end-stage renal disease RPC: reactive perforating collagenosis INTRODUCTION Perforating dermatosis is a heterogeneous group of disorders characterized by transepidermal elimination of dermal components such as collagen, elastin, or fibrin. Acquired perforating dermato...

We report the case of a 58-year-old woman who was considered to have died of cyclophosphamide (CPA)-induced late-onset lung disease. She underwent a right-sided mastectomy due to breast cancer at the age of 50 followed by daily administration of 50 mg CPA and 20 mg tamoxifen for 2 years. A refractory cough and dyspnea began at the age of 56. Chest radiographs revealed diffuse infiltrates and pl...