Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation.Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material,such as oils in a dry powder form.6 healthy volunteers ingested 4.6 g of fish oil containing 20% EPA in the form of ethyl-ester first alone and then as 1:1 microencapsulated powder ...

Cellular eicosapentaenoic acid (EPA) makes up approximately 3% of total fatty acids in Escherichia coli DH5α, a strain that carries EPA biosynthesis genes (pEPAΔ1). EPA was increased to 12% of total fatty acids when the host cell coexpressed the vector pGBM3::sa1(vktA), which carried the high-performance catalase gene, vktA. Where this vector was coexpressed, the transformant accumulated a larg...

OBJECTIVE The purpose of this study was to compare the efficacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the treatment of female subjects with borderline personality disorder. METHOD The authors conducted an 8-week, placebo-controlled, double-blind study of E-EPA in 30 female subjects meeting Revised Diagnostic Interview for Borderlines and DSM-IV criteria for borderline personal...

Studies have shown that fish oils, containing n-3 fatty acids, have protective effects against ischemia-induced, fatal cardiac arrhythmias in animals and perhaps in humans. In this study we used the whole-cell voltage-clamp technique to assess the effects of dietary, free long-chain fatty acids on the Na+ current (INa,alpha) in human embryonic kidney (HEK293t) cells transfected with the alpha-s...

Eicosapentaenoic acid (EPA) has been reported to have beneficial effects on the progression of various renal diseases including diabetic nephropathy; however, the precise mechanisms are not completely understood. We examined the effects of EPA on the early stage of type 2 diabetic nephropathy in KKA(y)/Ta mice and the possible role of inflammation, oxidative stress, and growth factor in this pr...

I am responding to the informative and well-written article by Drs. Yuan, Al-Shali, and Hegele entitled “Hypertriglyceridemia: its etiology, effects and treatments” as published in CMAJ April 10, 2007: 176 (8): 1103-1120. I wish to provide evidence-based information herein to correct statements made in this article with respect to the potential use of omega-3 fatty acids from fish oils in the f...

Introduction: Recent studies have shown that Polyunsaturated Fatty Acids (PUFAs), including Eicosapentaenoic Acid (EPA), and Arachidonic Acid (AA), are associated with cognitive functions in patients with Coronary Artery Disease (CAD). Nevertheless, controversial results have been reported, too. The current study aimed to clarify the association of serum EPA and AA levels with cognitive decline...