We investigated the pathways for low density lipoprotein (LDL) transport across an endothelial barrier in individually perfused microvessels before and after an increase in permeability. The divalent cation ionophore A23187 (5 microM) was used to increase microvessel permeability. LDL permeability coefficients (PsLDL) were measured using quantitative fluorescence microscopy. In the control stat...

A model function relating effective stress to fracture permeability is developed from Hooke's law, implemented in the tensorial form of Darcy's law, and used to evaluate discharge rates and pressure distributions at regional scales. The model takes into account elastic and statistical fracture parameters, and is able to simulate real stress-dependent permeabilities from laboratory to field stud...

It is essential to alter effective electromagnetic parameters of a material to enhance its response. In the present work, we propose a novel Left Hand Metamaterial (LHM) structure comprising double turn spiral resonator (DTSR) and capacitance loaded strips (CLS). This structure is numerically explored to examine the resonance and effective material parameters i.e. permeability and permittivity....

In this review we describe the challenges and opportunities for creating magnetically active metamaterials in the optical part of the spectrum. The emphasis is on the sub-wavelength periodic metamaterials whose unit cell is much smaller than the optical wavelength. The conceptual differences between microwave and optical metamaterials are demonstrated. We also describe several theoretical techn...

Live probiotic bacteria are effective in reducing gut permeability and inflammation. We have previously shown that probiotics release peptide bioactive factors that modulate epithelial resistance in vitro. The objectives of this study were to determine the impact of factors released from Bifidobacteria infantis on intestinal epithelial cell permeability and tight junction proteins and to assess...

The Golden Triangle is a visualization tool developed from in vitro permeability, in vitro clearance and computational data designed to aid medicinal chemists in achieving metabolically stable, permeable and potent drug candidates. Classifying compounds as permeable and stable and plotting molecular weight (MW) versus octanol:buffer (pH 7.4) distribution coefficients (logD) or estimated octanol...

Capillary pressure (Pc) curves acquired using the Magnetic Resonance Imaging (MRI) technique, call GIT-CAP, have 70-100 data points. This extra data, when compared with traditional porous plate or centrifuge techniques, allows for the interpretation of more information from the Pc curve. In particular, the pore throat size and relative permeability can be extracted. The pore throat size can be ...

[1] The slip behavior of major faults depends largely on the frictional and hydrologic properties of fault gouge. We report on laboratory experiments designed to measure the strength, friction constitutive properties, and permeability of a suite of saturated clay-rich fault gouges, including: a 50:50% mixture of montmorillonite-quartz, powdered illite shale, and powdered chlorite schist. Fricti...

The simulation of flow and transport phenomena in fractured media is a challenging problem. Despite existing advances in computer capabilities, the fact that fractures can occur over a wide range of scales within porous media compromises the development of detailed flow simulations. Current discrete approaches are limited to systems that contain a small number of fractures. Alternatively, conti...