نتایج جستجو برای: edss
تعداد نتایج: 1456 فیلتر نتایج به سال:
INTRODUCTION Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. The aim of this study is to examine the correlations between expanded disability status scale (EDSS) and cytokines after intervention with co-supplemented hemp se...
BACKGROUND Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS Sixty-five patients who underwent a spinal tap during relapse of relapsing/remitting multipl...
BACKGROUND The course of multiple sclerosis (MS) has been studied in several cohorts; however, results have varied significantly. OBJECTIVE To describe the clinical course of MS in a nationwide cohort of patients. METHOD Data from the Swedish MS register (SMSreg) were used to estimate the median time to the sustained Expanded Disability Status Scale (EDSS) scores 3.0, 4.0 and 6.0, onset of ...
مالتیپل اسکلروز (ms )، بیماری مزمن و ناتوان کننده سیستم عصبی مرکزی (cns )است و شایع ترین علت ناتوانی غیرجراحتی در جوانان می باشد. با توجه به گسترش و اهمیت این بیماری، بررسی کمی تغییرات در بافت مغز به همراه ارزیابی علایم بالینی، درک دقیق تری از روند پیشرفت و درمان بیماری ایجاد می کند. تصویربرداری تشدید مغناطیسی تانسور انتشاری (dt-mri )یک روش تصویربرداری حساس برای بررسی تغییرات آسیب شناسی بافت مغ...
هدف: تهیه ی نسخه ی فارسی مقیاس coop wonca و بررسی ویژگی های روانسنجی آن درافراد مبتلا به مالتیپل اسکلروزیس فارسی زبان ایرانی روش:197 بیمار مبتلا به ام اس در این طرح شرکت داشتند که مقیاس coop wonca توسط آنها تکمیل شد. 50 نفر به صورت داوطلبانه به فاصله ی چهار هفته، مجدداً به پرسشنامه جواب دادند. به منظور ارزیابی اعتبار سازه، نمره ی آیتم های این پرسشنامه با پرسشنامه ی کیفیت زندگی sf-36 و نمره ی نا...
Evoked potentials are widely used in diagnosis of multiple sclerosis (MS), but not sufficient data are available for their prospective role in the course of disease. The presentation is a longitudinal study in the Clinic of Neurology at MHAT – NHH – Sofia from Aug 2009 to Mar 2012. It includes 52 patients with clinically definite multiple sclerosis according to revised MacDonald criteria (2005/...
OBJECTIVE To compare whole-body fat mass and fat-free mass (FFM) in ambulatory patients with multiple sclerosis (MS) and control subjects without MS. DESIGN Nonrandomized controlled trial or cross-sectional study. SETTING An exercise physiology laboratory at a medical school. PARTICIPANTS Seventeen ambulatory patients with MS and 12 control subjects (all subjects were women). The median E...
BACKGROUND The aim of this preliminary study was to assess the safety and efficacy of high-dose oral vitamin D3 supplementation during pregnancy in women with multiple sclerosis (MS) in Isfahan, Iran. METHODS In a single center open-label randomized, controlled clinical Phase I/II pilot study, 15 pregnant women with confirmed MS with low serum 25-hydroxyvitamin D (25(OH)D) levels were randoml...
OBJECTIVES To develop a model of disease progression using multiple sclerosis (MS) as an exemplar. STUDY DESIGN AND SETTINGS Two observational cohorts, the University of Wales MS (UoWMS), UK (1976), and British Columbia MS (BCMS) database, Canada (1980), with longitudinal disability data [the Expanded Disability Status Scale (EDSS)] were used; individuals potentially eligible for MS disease-m...
OBJECTIVE To evaluate variability and predictability of disability trajectories in moderately advanced and advanced multiple sclerosis (MS), and their modifiability with immunomodulatory therapy. METHODS The epochs between Expanded Disability Status Scale (EDSS) steps 3-6, 4-6 and 6-6.5 were analysed. Patients with relapse-onset MS and having reached 6-month confirmed baseline EDSS step (3/4/...
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