Acute graft-versus-host disease (aGvHD) continues to be a major obstacle to allogeneic haematopoietic stem cell transplantation. Thymic damage secondary to aGvHD along with corticosteroids and other non-selective T lymphocyte-suppressive agents used in the treatment of aGvHD concurrently impair thymopoiesis and negatively impact on immunoreconstitution of the adaptive immune compartment and ult...

BACKGROUND AND OBJECTIVES Extracorporeal chemophototherapy (ECP) is considered an immunomodulatory agent useful in both acute and chronic graft-versus-host disease (GVHD). Little is known about the best treatment schedule, and there are no data concerning hematologic parameters and cellular compositions of products during the treatment. DESIGN AND METHODS This was a single-center study of 27 ...

The purpose of this study was to investigate the applicability of our newly developed technology (RACTAB® technology) for preparing orally disintegrating tablets (ODTs) containing enteric-coated particles. Tamsulosin hydrochloride (TAM) was used as a model drug contained in the enteric-coated particles. Enteric-coated particles containing TAM (ECP-T) were prepared by spray coating a mixture of ...

AIM To validate the use of tear eosinophil cationic protein (ECP) as a marker for eosinophil activation, and its pharmacological modulation, in addition to evaluating the efficacy of lodoxamide and sodium cromoglycate in the treatment of vernal keratoconjunctivitis (VKC). METHODS Tears were collected from 30 patients affected by active mild to moderate VKC before and after therapy with disodi...

Background: Psoriatic erythroderma may occur in relation to withdrawal of systemic or topical steroids, and its pathogenesis is unclear. Objective: To investigate serum Adenosine deaminase (ADA) activity in patients with erythroderma and its correlation to malondialdehyde (MDA), total antioxidant capacity (TAC) and eosinophil cationic protein (ECP). Patients and methods: 26 patients with erythr...

To investigate whether eosinophils are stimulated in vivo or have acquired an increased susceptibility to stimuli from the coagulation cascade, the release of eosinophil proteins was compared for three groups of donors with different levels of serum IgE. (1) with atopic dermatitis (s-IgE > 5000 IU/ml, n = 11); (2) with inhalant allergy (200 < s-IgE < 2 000 IU/ml, n = 10); and (3) non-allergic (...

OBJECTIVES Emergency contraception pills (ECP) are among the 13 essential commodities in the framework for action established by the UN Commission on Life-Saving Commodities for Women and Children. Despite having been on the market for nearly 20 years, a number of barriers still limit women's access to ECP in low- and middle-income countries (LMIC) including limited consumer knowledge and poor ...

Antibody production and clinical efficacy (relative percent survival RPS) were measured in 40±5g rainbow trout after immunization with two types of Streptococcus iniae vaccines consisting of formalin killed cells (FKC) and FKC enriched with the bacterial extracellular products (ECP) administered by intraperitoneal (i.p), immersion and oral routes at 16±1 ̊C for 18 weeks. No significant differenc...

Presenting Residents Gema E. Fernandez, MD Contraception: knowledge, lifestyles, and behaviors. G.E. Fernandez, MD; M. Phipps, MD, MPH; R. Shackelton; F. Lozowski; A. Meers. Objective: Efforts to make ECP available over the counter have been unsuccessful to date for many reasons, including claims that ECP encourages irresponsible sexual behavior and will increase rates of sexually transmitted d...

OBJECTIVE The objective of this study was to evaluate the effect of an intervention with advance provision of emergency contraceptive pills (ECP), condoms, and extended information to a targeted group of teenage girls, compared with a control group, 12 months after intervention. MATERIAL AND METHODS A randomized controlled trial among 420 girls, 15-19 years old, requesting emergency contracep...