OBJECTIVES The present investigation was designed to determine if atrial natriuretic peptide (ANP) gene expression increases in extracardiac as well as within the heart in congestive heart failure. METHODS Congestive heart failure (CHF) was induced by producing cardiac hypertrophy secondary to an aortocaval fistula in Sprague-Dawley rats. To characterize this model, control and CHF rats had c...

Despite current treatments, including use of angiotensin-converting enzyme (ACE) inhibitors, digoxin, and diuretics, morbidity and mortality remain alarmingly high. An estimated 50% of patients with severe signs and symptoms of heart failure will die within 1 year and 70% within 3 years. Additional pharmacological therapies to mitigate this disorder, such as β-blockers, continue to be investiga...

Although the incidence of coronary heart disease (CHD) has decreased in United States, acute myocardial infarction (AMI) remains a major medical problem. Many patients still need emergency care department (ED) due to complications mechanical, inflammatory, and embolic factors. This summary aims provide brief available evidence clinical medicine regarding evaluation management after infarction. ...

OBJECTIVE Rapid ventricular pacing in dogs results in a low output cardiomyopathic state similar to idiopathic dilated cardiomyopathy in man. Cell death by apoptosis may play an important role in the loss of cardiac function. This study investigates the molecular pathways involved in the regulation of apoptosis in dogs with pacing-induced heart failure. METHODS Apoptosis was identified by ter...

A 71-year-old male presented with atypical chest pain and dilatation of the right ventricle on echocardiography and was referred for cardiac magnetic resonance imaging (CMR) for suspected arrhythmogenic right ventricular cardiomyopathy. CMR showed marked posterior and leftward displacement of the heart, with the apex extending to the left lateral chest wall. Spin echo imaging showed thin perica...

Vein of Galen aneurysmal malformation (VGAM) is a rare congenital malformation, accounting for less than 1% of cerebrovascular abnormalities. The majority of reported cases have been associated with congestive heart failure (CHF) in the neonatal period. Herein, we present a case of VGAM, diagnosed at 37 weeks of gestation during the intrauterine life Case report: A full-term female newborn pre...

Background: Cardiac dysfunction is one of the major causes of morbidity and mortality in thalassemia patients. This study aimed to compare the effect of Brain Natriuretic Peptides (BNP) and Calcitonin Gene-Related Peptide (CGRP) with echocardiographic findings in early diagnosis of cardiac disease in major thalassemia patients. Materials and Methods: This study was performed on 80 patients amo...

BACKGROUND Previous research has demonstrated the prognostic value of echocardiography with tissue Doppler imaging (TDI) in the heart failure (HF) population. Heart rate recovery (HRR) has also recently shown promise as a prognostic marker. HYPOTHESIS We hypothesize echocardiography with TDI and HRR will be significantly correlated and both will provide prognostic information. METHODS A tot...

Natriuretic peptides were discovered in 50-70s of the XX century. BNP was more diagnostically and prognostically significant, as it is secreted directly into the ventricles of the heart. The studies demonstrated a high predictive value of increasing the level of BNP in acute decompensation of heart failure and in patients with chronic heart failure in a study of Val-HeFT It was demonstrated tha...

we investigated neuronal uptake of noradrenaline (na) at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear vein) in a model devised to mimic heart failure. the model presented here is the rabbit coronary ligation model in which myocardial infarction w...