نتایج جستجو برای: ebv
تعداد نتایج: 8851 فیلتر نتایج به سال:
Morbidity and mortality of immunocompromised patients are increased by primary infection with or reactivation of Epstein-Barr virus (EBV), possibly triggering EBV+ post-transplant lymphoproliferative disease (PTLD). Adoptive transfer of EBV-specific cytotoxic T cells (EBV-CTLs) promises a non-toxic immunotherapy to effectively prevent or treat these complications. To improve immunotherapy and i...
Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both B and epithelial cells, and determines EBV susceptibility of non-B cells. Here we show that neuropilin 1 (NRP1) direc...
Epstein–Barr virus (EBV) infection is present in 10% of gastric cancer cases and plays a role in carcinogenesis. HER2 expression has received increasing attention since the efficacy of an anti-HER2 antibody, trastuzumab, in gastric cancer with HER2 overexpression was shown. However, a significantly lower frequency of HER2 overexpression has been observed in EBV+ gastric cancers. The aim of this...
INTRODUCTION There is a suspicion of increased risk of Epstein-Barr virus (EBV)-associated lymphoproliferations in patients with inflammatory arthritides receiving immunosuppressive drugs. We investigated the EBV load and EBV-specific T-cell response in patients treated with methotrexate (MTX) or anti-TNF therapy. METHODS Data for patients with rheumatoid arthritis (RA) (n = 58) or spondylart...
سابقه و هدف: لانگرهانس هیستیوسیتوزیس یک بیماری نادر می باشد که بافت های مختلفی را در گیر میکند. از آنجائیکه ویروسها بعنوان عوامل احتمالی ایجاد لانگرهانس سل هیستیوسیتوزیس مطرح شده اند. لذا این مطالعه به منظور بررسی ارتباط ویروسهای DNA دار و لانگرهانس سل هیستیوسیتوزیس در کودکان ایرانی انجام شد. مواد و روش ها: در این مطالعه مورد-شاهدی، بلوک های پارافینی 48 بیمار با تشخیص بالینی و میکروسکپی لانگرها...
هدف از این مطالعه بررسی پیشرفت ژنتیکی، افزایش میانگین همخونی و پیشبینی صحت ارزیابی تحت طرحهای آمیزشی مختلف با استفاده از شبیهسازی بود. دو وراثتپذیری مختلف (1/0 و 5/0) و پنج طرح آمیزشی شامل آمیزش تصادفی (rnd)، آمیزش براساس حداقل همخونی (minf)، آمیزش براساس حداکثر همخونی (maxf)، آمیزش جور شده مثبت براساس فنوتیپ (phen) و آمیزش جور شده مثبت براساس ارزش اصلاحی پیشبینیشده (ebv) در نظر گرفته شد...
Epstein-Barr virus (EBV)-associated lymphoproliferative disorder (LPD) is a serious complication after allogeneic bone marrow transplantation (BMT). Dynamics of EBV-specific cytotoxic T lymphocytes (CTL), which are important in controlling EBV during the LPD, have not been fully elucidated. A patient with Wiskot-Aldrich's syndrome was diagnosed as suffering from LPD on day 47 after BMT. Fluores...
A system of 3H-thymidine incorporation by lymphocytes in culture for 3 wk has been utilized for quantitative assessment of the ability of T lymphocytes to inhibit outgrowth of autologous Epstein-Barr virus (EBV) transformed B lymphocytes. Lymphocytes from EBV-seronegative individuals lack the ability to suppress outgrowth of autologous EBV-transformed B lymphocytes. This capability appears duri...
Circular Epstein-Barr virus (EBV) DNA molecules have been purified and characterized from a human lymphoid cell line derived from a case of heterophile antibody-positive, blood transfusion-induced infectious mononucleosis, 883L. The circular EBV DNA in three cell lines obtained by transformation of human umbilical cord blood leukocytes with a strain of EBV originally derived from 883L was also ...
In the present study, Epstein-Barr virus (EBV) isolates from 18 malignant tumors (angioimmunoblastic lymphadenopathy [AILD], n = 4; Hodgkin's disease [HD], n = 3; pleomorphic T-cell non-Hodgkin's lymphoma [T-NHL], n = 1; B-cell non-Hodgkin's lymphoma [B-NHL], n = 8; gastric carcinoma, n = 2) as well as from 10 tonsils of EBV-seropositive children and from peripheral blood mononuclear cells of 1...
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