Dielectrophoresis (DEP) has emerged as an important tool for the manipulation of bioparticles ranging from the submicron to the tens of microns in size. Here we show the use of phospholipid vesicle electroformation techniques to develop a new class of test particles with specifically engineered electrical propserties to enable identifiable dielectrophoretic responses in microfabricated systems....

experimental autoimmune vitiligo was induced by the intradermal injection of the purified mushroom tyrosinase emulsified in complete freund’s adjuvant (cfa) in female c57bl/6 mice. the onset of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. oral administration of semipurified mushroom tyrosinase prevented experimental auto...

Entity-Attribute-Value (EAV) data, as present in repositories of clinical patient data, must be transformed (pivoted) into one-column-per-parameter format before it can be used by a variety of analytical programs. Pivoting approaches have not been described in depth in the literature, and existing descriptions are dated. We describe and benchmark three alternative algorithms to perform pivoting...

We derive a new algorithm for computing the action f(A)V of the cosine, sine, hyperbolic cosine, and hyperbolic sine of a matrix A on a matrix V , without first computing f(A). The algorithm can compute cos(A)V and sin(A)V simultaneously, and likewise for cosh(A)V and sinh(A)V , and it uses only real arithmetic when A is real. The algorithm exploits an existing algorithm expmv of Al-Mohy and Hi...

The paper provides an overview of neuroinformatics research at Yale University being performed as part of the national Human Brain Project. This research is exploring the integration of multidisciplinary sensory data, using the olfactory system as a model domain. The neuroinformatics activities fall into three main areas: 1) building databases and related tools that support experimental olfacto...

The action of the matrix exponential on a vector eAtv, A∈Cn×n, v∈Cn, appears in problems that arise mathematics, physics, and engineering, such as solution systems linear ordinary differential equations with constant coefficients. Nowadays, several state-of-the-art approximations are available for estimating this type action. In work, two Taylor algorithms proposed computing eAv, which make use...

Many clinical research databases are built for specific purposes and their design is often guided by the requirements of their particular setting. Not only does this lead to issues of interoperability and reusability between research groups in the wider community but, within the project itself, changes and additions to the system could be implemented using an ad hoc approach, which may make the...