BACKGROUND Endogenous uveitis is a chronic inflammatory eye disease of human, which frequently leads to blindness. Experimental autoimmune uveoretinitis (EAU) is an animal disease model of human endogenous uveitis and can be induced in susceptible animals by immunization with retinal antigens. EAU resembles the key immunological characteristics of human disease in that both are CD4(+) T-cell me...

Uveitis is a complex multifactorial autoimmune disease of the eye characterized by inflammation of the uvea and retina, degeneration of the retina, and blindness in genetically predisposed patients. Using the rat model of experimental autoimmune uveitis (EAU), we previously identified three quantitative trait loci (QTL) associated with EAU on rat chromosomes 4, 12, and 10 (Eau1, Eau2, and Eau3)...

The European Association of Urology (EAU) delved into the very latest in urological science at 37th Annual Congress, EAU22, on 1st–4th July Amsterdam, Netherlands. four days were filled to brim with 2,580 presentations by more than 900 speakers, and 56 courses organised School (ESU). This included six Game Changing sessions, a day live surgery, eight plenary Section meetings, Beyond Europe, pos...

JEM © The Rockefeller University Press $30.00 Vol. 205, No. 4, April 14, 2008 799-810 www.jem.org/cgi/doi/ 799 10.1084/jem.20071258 IL-23 is a recently described member of the IL-12 family. Both cytokines share a common p40 subunit, but IL-23 has a unique p19 subunit whereas IL-12 uses a p35 subunit ( 1 ). IL-12 and IL-23 promote overlapping as well as distinct cellular immune functions. Wherea...

AIMS Administration of unfractionated retinal antigen(s) (retinal extract, RE) suppresses RE induced experimental autoimmune uveoretinitis (EAU) and offers a potential therapeutic alternative to non-specific immunosuppressive therapies for posterior uveitis and autoimmune diseases. S-Ag and interphotoreceptor retinoid binding protein (IRBP) are two major autoantigens within soluble RE. It was a...

guidelines are not ‘upgraded’ following panel consensus. This statement further confused me. After discussing and analyzing this information with some andrological experts in China and abroad, I decided to express my perspectives on this problem. The estrogen receptor modulator, tamoxifen, when combined with testosterone undecanoate (TU), was shown to be an effective treatment choice for male i...

m We have su~ested a role for nitric oxide as a mediir of the autoimmune dcattuaion of tbe retina in our rat model of EAU. ln orevious immunohktochanical studies we detected the iNOS enzyme only dkng and at the site of active disease, c&xalising’tith activated ED1 positive macrophages intiltrating the retina. The ah of this study was to detect iNOS mRNA and investigate the eqreasion of intlamma...

m We have su~ested a role for nitric oxide as a mediir of the autoimmune dcattuaion of tbe retina in our rat model of EAU. ln orevious immunohktochanical studies we detected the iNOS enzyme only dkng and at the site of active disease, c&xalising’tith activated ED1 positive macrophages intiltrating the retina. The ah of this study was to detect iNOS mRNA and investigate the eqreasion of intlamma...

m We have su~ested a role for nitric oxide as a mediir of the autoimmune dcattuaion of tbe retina in our rat model of EAU. ln orevious immunohktochanical studies we detected the iNOS enzyme only dkng and at the site of active disease, c&xalising’tith activated ED1 positive macrophages intiltrating the retina. The ah of this study was to detect iNOS mRNA and investigate the eqreasion of intlamma...