Viral replication relies on host metabolic machinery and precursors to produce large numbers of progeny - often very rapidly. A fundamental example is the infection of Escherichia coli by bacteriophage T7. The resource draw imposed by viral replication represents a significant and complex perturbation to the extensive and interconnected network of host metabolic pathways. To better understand t...

Data Grid is a type of Grid Computing systems whichis designed to provide geographically distributed data resources to large computational problems that require mining and evaluating large amounts of data. Managing this data in a centralized location increases the data access time and hence much time is taken to execute the job. So to reduce the data access time, "Replication" is used. Data rep...

Abstract Broadcasting in Ad hoc networks is an important information dissemination way. However, flooding may give rise to broadcast storm problem which causes severe contention, collision and delay. This paper proposes a dynamic probabilistic algorithm based on neighbour discovery that ensures the higher reliability at lower retransmission. The forwards from node (INode) has obtained it (UNode...

SRC kinases and PKR are intracellular protein kinases, which play key roles in intracellular viral replication. In this research, the effect of SRC kinase inhibition and PKR activation and inhibition on replication of coxsakievirus (CVB3), an entrovirus of the family picornaviridae – causative agents of fatal myocarditis, was studied. Vero and Hela cells were cultured and infected with CVB3 in ...

objective: in this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. dna topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as dna replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the dna. result...

abstract— data grids are an important branch of gird computing which provide mechanisms for the management of large volumes of distributed data. energy efficiency has recently emerged as a hot topic in large distributed systems. the development of computing systems is traditionally focused on performance improvements driven by the demand of client's applications in scientific and business ...

conclusions after seven consecutive passages of both cell cultures, the h9n2 virus showed similar antigenicity, also no change on viral titer level and virus replication behavior in adaptation was found. the results highlighted the use of a549 cells for efficient virus isolation. results the influenza virus infectivity was not significant difference in these cells in the presence of trypsin. th...

The two classic theories for the existence of sexual replication are that sex purges deleterious mutations from a population1-7, and that sex allows a population to adapt more rapidly to changing environments8-11. These two theories have often been presented as opposing explanations for the existence of sex. Here, we develop and analyze evolutionary models based on the asexual and sexual replic...

To maintain genomic stability, reinitiation of eukaryotic DNA replication within a single cell cycle is blocked by multiple mechanisms that inactivate or remove replication proteins after G1 phase. Consistent with the prevailing notion that these mechanisms are redundant, we previously showed that simultaneous deregulation of three replication proteins, ORC, Cdc6, and Mcm2-7, was necessary to c...

As the Internet is evolving away from providing simple connectivity towards providing more sophisticated services, it is difficult to provide efficient delivery of high-demand services to end-users due to the dynamic sharing of the network and connected servers. To address this problem, we propose the service grid architecture that incorporates dynamic replication and deletion of services