Late complications following endovascular aneurysm repair indicate the need for long-term surveillance. Clinical trials involving endoluminal stent grafts have typically used computed tomography angiography as the main imaging modality for surveillance. However, computed tomography angiography exposes the patient to higher levels of ionizing radiation, nephrotoxic agents, and increased cost com...

The physical properties of the DNA oligomer d(CGCGCGTTTTCGCGCG) in solvents containing 4 M NaClO4 and 0.1 M NaCl were investigated by proton NMR, optical melting, and circular dichroism spectroscopy. Results of these investigations are as follows: (i) The DNA hexadecamer exists as a unimolecular hairpin in either high or low salt. (ii) In high salt the stem region of the hairpin is in the left-...

Small molecules that intercalate in DNA and RNA are powerful agents for controlling nucleic acid structural transitions. We recently demonstrated that coralyne, a small crescent-shaped molecule, can cause the complete and irreversible disproportionation of duplex poly(dA)*poly(dT) into triplex poly(dA)*poly(dT)*poly(dT) and a poly(dA) self-structure. Both DNA secondary structures that result fr...

Duplex services are multimedia services that requires good connectivity in both uplink and downlink such as VoIP, video conferencing and interactive gaming. A weak connection in either directionmay cause degradation of performances and dissatisfaction of user experience.Most researchers do not consider this issue and treat resource allocations in uplink and downlink independently. For this reas...

The synthesis of neomycin covalently attached at the C5-position of 2'-deoxyuridine is reported. The synthesis outlined allows for incorporation of an aminoglycoside (neomycin) at any given site in an oligonucleotide (ODN) where a thymidine (or uridine) is present. Incorporation of this modified base into an oligonucleotide, which is complementary to a seven-bases-long alpha-sarcin loop RNA seq...

Assignment of the 1H and 31P NMR spectra of a decamer oligodeoxyribonucleotide duplex, d(CCCGATCGGG), and its quinoxaline ((MeCys3, MeCys7]TANDEM) drug duplex complex has been made by two-dimensional 1H-1H and heteronuclear 31P-1H correlated spectroscopy. The 31P chemical shifts of this 10 base pair oligonucleotide follow the general observation that the more internal the phosphate is located w...

As an alternative to the pressure swing adsorption (PSA) based on the Skarstrom cycle or its variants, a novel two-bed PSA--called duplex PSA--has been proposed by Hirose and independently by Leavitt to get both products of high purities. Simulation and experimental studies on duplex PSA for CO2 capture indicate that CO2 can be enriched to 95 mol% of feed containing 20 mol% CO2 and 80 mol% N2. ...

PURPOSE Ribonucleotide reductase (RR) is a therapeutic target for DNA replication-dependent diseases such as cancer. Here, a potent small interfering RNA (siRNA) duplex against the M2 subunit of RR (RRM2) is developed and shown to reduce the growth potential of cancer cells both in vitro and in vivo. EXPERIMENTAL DESIGN Three anti-RRM2 siRNAs were identified via computational methods, and the...

This paper considers a cellular system with a fullduplex base station and half-duplex users. The base station can activate one user in uplink or downlink (half-duplex mode), or two different users one in each direction simultaneously (full-duplex mode). Simultaneous transmissions in uplink and downlink causes self-interference at the base station and uplinkto-downlink interference at the downli...