Much of the confusion of thought and teaching which now exists regarding the surgical management of patients suffering from chronic gastric and chronic duodenal ulcer arises from the fact that in recent years it has become customary to class these two conditions together as one disease-peptic ulcer. It is true that chronic gastric and chronic duodenal ulcer have certain features in common; the ...

The variations in size of the alkaline area of the gastric mucosa in disorders such as gastric ulcer, duodenal ulcer, and combined gastric and duodenal ulcer have been reported previously (Capper, Laidlaw, Buckler, and Richards, 1962; Capper, Butler, Buckler, and Hallett, 1966). The areas were defined at operation using a pH monitoring system, and were confirmed histologically afterwards. Recen...

the effect of bleeding duodenal ulcer on the diagnostic tests for h.pylori infection

The duodenal ulcer promoting (dupA) gene, located in the plasticity region of Helicobacter pylori, is associated with duodenal ulcer development. dupA was predicted to form a type IV secretory system (T4SS) with vir genes around dupA (dupA cluster). We investigated the prevalence of dupA and dupA clusters and clarified associations between the dupA cluster status and clinical outcomes in the U....

The literature, and particularly the statistical evaluation of peptic ulcer, is vast and ordinarily there should be little excuse for adding to it, unless one has some definite reason. It is well recognized that all over the world this disease pattern in the last few decades has undergone certain changes with regard to the duodenal-gastric ulcer ratio, sex incidence, and the occurrence of compl...

Maximal acid output (MAO) after pentagastrin stimulation and gastrin response to a standard meal was studied in 100 control and 200 duodenal ulcer subjects from each of two ethnic groups, Scots and Chinese. The acid output was significantly higher in the Scots than in the Chinese for both controls and duodenal ulcer patients. Despite correction for differences in body stature by expressing MAO ...

The hom family of Helicobacter pylori outer-membrane proteins, especially the homB gene, has been suggested as a novel virulence factor; however, the clinical association and function of this gene are still unclear. We evaluated the presence of the homA, homB, and cagA genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, ...

A dose response study of the effect on gastric acid secretion of synthetic human gastrin-17 in doses of 50,200, and 500 ng/kg/h was performed in eight healthy volunteers and in eight patients with duodenal ulcer. The study was repeated on a separate day during intravenous infusion of calcium gluconate (0.1 mmol Ca2+/kg/h). In healthy subjects the acid response to the combined infusion of synthe...

Most discussions about the aetiology of duodenal ulcer depict the duodenal bulb as a battlefield, on which aggressive and defensive factors wage a continuous and continuing campaign for the integrity of the bulbar mucosa. When the scales are tipped in favour of aggression, an ulcer develops. The battlefield is unique, because it is chemical warfare that is usually thought to be taking place hen...

OBJECTIVE To determine the frequency of peptic ulcer disease in patients on nonsteroidal anti-inflammatory drugs (NSAID). METHODS Record of eight hundred and twenty consecutive patients undergoing upper gastrointestinal (GI) endoscopy; from January 1998 to December 2000 were reviewed. The endoscopic diagnosis varied from gastritis, peptic ulcer to duodenitis. The use of NSAID was documented b...