Shiga toxin (Stx) is a major virulence factor of Stx-producing Escherichia coli. Recently, we developed a therapeutic Stx neutralizer with 6 trisaccharides of globotriaosyl ceramide, a receptor for Stx, in its dendrimer structure (referred to as "SUPER TWIG [1]6") to function in the circulation. Here, we determined the optimal structure of SUPER TWIG for it to function in the circulation and id...

Study Design Case report. Objective To present a rare case of hydrocephalus following bilateral dumbbell-shaped C2 spinal neurofibromas resection and postoperative cervical pseudomeningocele in a patient with neurofibromatosis type 1 (NF1). Methods The patient's clinical course is retrospectively reviewed. A 37-year-old man affected by NF1 referred to our department for progressive weakness of ...

A one-stage anterior approach was performed in four patients for total removal of dumbbell type neurinoma at the cervical level. In each case, the neurinoma compressed the spinal cord in the cervical canal, developed anteriorly through the intervertebral foramen, and compressed the vertebral artery. A conventional cervical anterior approach at the tumor site was performed, followed by confirmat...

Neurinomas originating from intercostal nerve roots can grow both inside and outside of the spinal canal, forming dumbbell-shaped tumors. Such a neurinoma was discovered at the Th3 and Th4 levels in a 73-year-old woman during evaluation for breast cancer surgery. Magnetic resonance images (MRI) showed spinal cord compression by the tumor despite lack of neurologic symptoms. The tumor was resect...

We study the demixing transition of mixtures of equal size hard spheres and dipolar hard spheres using computer simulation and integral equation theories. Calculations are carried out at constant pressure, and it is found that there is a strong correlation between the total density and the composition. The critical temperature and the critical total density are found to increase with pressure. ...

A novel compact microstrip lowpass filter (LPF) is proposed in this paper, which consists of the complementary rectangle split ring defected microstrip structure (CRSR-DMS), open stubs, spurline and the dumbbell-shaped defected ground structure (DGS). Due to the unique response of the presented CRSR-DMS, a low passband insertion loss and a sharp transition of the proposed LPF was achieved. Mean...

Structure formation in experimental monolayers of dumbbell particles is explored and compared to Brownian dynamics simulations. Probability densities shape factors found Voronoi tessellations allow for an in-depth analysis structural motifs.

An 80-year-old man, exposed to asbestos in a dockyard, suffered from progressive paraplegia for two months. His plantar reflexes were bilaterally abnormal and Romberg’s sign was positive. Spine MRI revealed that the thoracic cord was compressed by the mass in the dorsal epidural space (Picture 1). Chest CT was suggestive of mesothelioma with dumbbell-shaped progression spreading from the right ...

In this article we report on the controlled synthesis of asymmetric lemon-shaped and dumbbell-shaped multi-compartment nanoparticles (MCPs) with a reactive surface and interesting morphology. In our approach we utilize partial coating of hematite ellipsoids with a hydrophobic polymer layer followed by selective silica deposition on the non-coated surface. Ellipsoidal hematite particles provide ...

Abstract Systems coupling fluids and polymers are of great interest in many branches of sciences. One of the most classical models to describe them is the FENE (Finite Extensible Nonlinear Elastic) dumbbell model. We prove global existence of weak solutions to the FENE dumbbell model of polymeric flows. The main difficulty is the passage to the limit in a nonlinear term that has no obvious comp...