Aldolase catalyses the reversible splitting of fructose 1 :6-diphosphateto glyceraldehyde-3-phosphate and dihydroxy-acetone phosphate. Diagnostically it is of value in distinguishing primary muscular disease from neurogenic muscular atrophy. Most investigators agree that levels are higher in normal children, especially the newly born, than in normal adults and that there is no sex difference (S...

Duchenne muscular dystrophy (DMD), an X-linked disorder, is the most common muscular dystrophy in children, presenting in early childhood and characterized by proximal muscle weakness and calf hypertrophy in affected boys. Patients usually become wheelchair-bound by the age of 12 years, and die of cardiorespiratory complications in their late teens to early twenties. Advances in the management ...