In the Netherlands, teaching programs for French as a foreign language in secondary school usually involve an explicit focus on grammar. This is partially motivated by early findings SLA research, which showed that instruction more effective acquisition (Norris, & Ortega, 2000; Spada, Tomita, 2010) and even considered essential to achieve accuracy advanced writing (Gunnarsson, 2012). The ai...

Thank you for submitting your manuscript on the identification of DUB function in the TYMV protease for consideration by The EMBO Journal. Three referees have now provided their comments, which are copied below. As you will see, the referees appreciate that your study (for the most part convincingly) establishes TYMV 98K as a bona fide new example of a viral DUB enzyme, although a few open ques...

We conducted a systematic review to evaluate the efficacy and safety of Chinese herbal medicine (CHM) for dysfunctional uterine bleeding (DUB) by performing a meta-analysis. Randomized controlled trials (RCTs) or quasi-RCTs comparing CHM vs no treatment, placebo, conventional western medicine (CWM), or general non-specific surgical treatment for DUB were identified by electronic and manual sear...

Dysregulation of the UPS (ubiquitin-proteasome system) has been implicated in a wide range of pathologies including cancer, neurodegeneration and viral infection. Inhibiting the proteasome has been shown to be an effective therapeutic strategy in humans; yet toxicity with this target remains high. DUBs (deubiquitinating enzymes) represent an alternative target in the UPS with low predicted toxi...

Rap80 targets the breast cancer suppressor protein BRCA1 along with Abraxas and the BRCC36 deubiquitinating enzyme (DUB) to polyubiquitin structures at DNA double-strand breaks (DSBs). These DSB targeting events are essential for BRCA1-dependent DNA damage response-induced checkpoint and repair functions. Here, we identify MERIT40 (Mediator of Rap80 Interactions and Targeting 40 kD)/(C19orf62) ...

Debiased recommendation with a randomized dataset has shown very promising results in mitigating system-induced biases. However, it still lacks more theoretical insights or an ideal optimization objective function compared the other well-studied routes without dataset. To bridge this gap, we study debiasing problem from new perspective and propose to directly minimize upper bound of function, w...

Aneuploidy, the unbalanced segregation of chromosomes during cell division, is recurrent in many tumors and the cause of birth defects and genetic diseases. Centromeric chromatin represents the chromosome attachment site to the mitotic spindle, marked by specialized nucleosomes containing a specific histone variant, CEN-H3/Cse4, in yeast. Mislocalization of Cse4 outside the centromere is delete...