Background AK119 is an Fc-engineered humanized IgG1 monoclonal antibody targeting human CD73. CD73-extracellular adenosine pathway regulates conversion of pro-inflammatory and immuno-stimulatory extracellular ATP into immunosuppressive adenosine. CD73 expresses on cancer cells, endothelial fibroblasts, lymphocytes myeloid cells. upregulated can be a result tissue hypoxia, 1 epithelial-to-mesenc...