Although enzymes of nonhuman origin have been studied for a variety of therapeutic and diagnostic applications, their use has been limited by the immune responses generated against them. The described dual-porosity hollow nanoparticle platform obviates immune attack on nonhuman enzymes paving the way to in vivo applications including enzyme-prodrug therapies and enzymatic depletion of tumor nut...

In this paper, we present two algorithms for shape-based porosity measures. Specifically, we describe two innovative attributes called perimeter porosity and area porosity as feature descriptors. Perimeter porosity refers to how “porous” or “weak” an image object is, while area porosity determines the degree of “branchiness” of an object. We show the applicability of the two measures through a ...

For this study we selected 20 drill cores covering a wide range of depths (400-3000 m), from 15 wells, that provide a reasonable coverage of the field. Only andesite, the largely predominant rock type in the field, was included in this sample. We measured bulk density, grain (solids) density, effective porosity and (matrix) permeability on a considerable number of specimens taken from the cores...

Natural and anthropogenic fractured aquifers reservoirs are dual porosity matrix-fracture systems, where the fracture network provides highly–conductive flow pathways low–permeability matrix stores most of fluid. The coupling between mechanical deformation in media is often modeled using classical theory dual-porosity poroelasticity (DPP), based on Barenblatt's hypothesis pressure equilibrium i...

We present an investigation of the scale dependence of hydraulic 3 parameters in fractured media based on the concept of transfer functions (TF). 4 TF methods provide an inexpensive way to perform aquifer parameter es5 timation, as they relate the fluctuations of an observation time series (hy6 draulic head fluctuations) to an input function (aquifer recharge) in frequency 7 domain. Fractured m...

Bioinspired Perspiration Wicking Inspired by the active liquid transport phenomenon in nature, article number 2200961, Hao Wu, Zhuo Li, and co-workers develop a biomimetic Au/TPU/CM based e-skin with dual porosity surface energy gradient to unidirectionally drain sweat away from skin, preventing signal degradation wearing discomfort caused perspiration accumulation.

Microporous membranes have a number of applications in microfluidic devices including biotechnology and displays (Hagedon et al 2012 Nature Commun. 3 1173, De Jong et al 2006 Lab Chip 6 1125–39). Though commercially available micro-porous membranes are widely available using the ion track-etch method, there are few economical techniques to make mechanically robust membranes with dual pore sizes...

Department of Chemistry and Biochemistr MD, 20742, USA. E-mail: [email protected]; Te Department of Materials Science and Engi Park, MD, 20742, USA Department of Chemical and Biomolecula College Park, MD, 20742, USA Institute for Systems Research, University of † Electronic supplementary information mesopore volume difference and the sp OMCNW/Fe2O3; N2 adsorption–desor distributions of single templa...

Electroporation is the application of electric pulses of sufficient amplitude to target tissue, which entails not only permeabilization of cell membranes, but also heat generation and dissipation. Noticeable rises in temperature have been observed in a number of electroporation applications. These temperature rises are a potential source of alteration of thermodynamic properties of tissue where...

[1] In this study, we used porosity to assess the compaction state of the Nankai accretionary wedge sediments and any implications for stress and pore pressure. However, hydrous minerals affect porosity measurements, and accounting for them is essential toward defining the interstitial porosity truly representative of the compaction state. The water content of sediments was measured in core sam...