Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Humans can easily infer the motivations behind human actions from only visual data by comprehensively analyzing complex context information and utilizing abundant life experiences. Inspired humans’ reasoning ability, existing motivation prediction methods have improved image-based deep classification models using commonsense knowledge learned pre-trained language models. However, public text co...

Location and types of sensors may be integrated for simultaneous achievement of water security goals and other water utility objectives, such as regulatory monitoring requirements. Complying with the recent recommendations on dual benefits of sensors, this study addresses the optimal location of these types of sensors in a multipurpose approach. The study presents two mathematical models for ...

Although mutations in cardiac myosin binding protein-C (cMyBP-C) cause heart disease, its role in muscle contraction is not well understood. A mechanism remains elusive partly because the protein can have multiple effects, such as dual biphasic activation and inhibition observed in actin motility assays. Here we develop a mathematical model for the interaction of cMyBP-C with the contractile pr...