We studied the mechanism of post-overdrive suppression in superfused rabbit sinus node pacemaker cells. Small specimens of sinus node tissue isolated from rabbit hearts were driven at a fast rate (overdrive) for 10-120 seconds using single sucrose gap methods. During the control perfusion (35 degrees C Tyrode's solution), overdrive caused a progressive decrease in maximum diastolic potential (M...

Abstract The need to optimize investments in bridge maintenance has created a demand for improved management systems (BMS). Outdated practices inspection and constant advances information technology have also contributed this demand. use of Digital Twins (DT), although well established other industries, is still incipient asset structural analysis bridges. There great deal research on Building ...

Single crystals o f anhydrous thymine (T), thymine monohydrate (T ■ H 20 ) , 5,6-dihydrothymine (TH 2), 1-methylthymine (mT) and thymidine (dT) were irradiated with X-rays and UV between 77 K and 300 K. Six types o f radicals were analyzed by ESR-spectroscopy at 9.5 GHz and 35 GHz after exposure to X-rays. The anion radical occurred only in T • H 20 at 77 K, the 4-yl radical only in TH 2 at 77 ...

In rats, both central and systemic ANG II type 1 (AT(1)) receptor blockade attenuate sympathetic hyperactivity, but central blockade more effectively attenuates left ventricular (LV) dysfunction post-myocardial infarction (MI). In protocol I, we examined whether functional effects on cardiac load may play a role and different cardiac effects disappear after withdrawal of the blockade. Wistar ra...

Insulin induces cardioprotection partly via an antiapoptotic effect. However, the optimal timing of insulin administration for the best quality cardioprotection remains unclear. We tested the hypothesis that insulin administered prior to ischemia provides better cardioprotection than insulin administration after ischemia. Isolated rat hearts were prepared using Langendorff method and divided in...

S. Pajevic, P. J. Basser MSCL/CIT, National Institutes of Health, Bethesda, MD, United States, NICHD/STBB, NIH, Bethesda, MD, United States Introduction: Diffusion Tensor MRI (DTI) measures a diffusion tensor of water in tissue, fr om which useful micr ostructural information can be obtained [1]. DTI provides information about the local diffusion field from which one can attempt to reconstruct...

As the insulated gate bipolar transistor (IGBT) modules have their own specific characteristic switching forms, turn-on and turn-off times are changed according to practical applications. For conventional drives, resistors used adjust which change losses that a significant amount in total losses. Collector current rate of change, $di_{C}/ dt$ collector-emitter $dv_{CE}/ dependent on each other ...

PURPOSE To develop a laboratory model aimed at duplicating the failure process of post and core restorations. The load pattern applied was to be repetitive (fatigue) and multivectorial. To determine and compare the resistance under fatigue loading of seven endodontic post/natural root combinations: stainless steel-, titanium-, ceramic-, composite-fiber/epoxy-, two glass-fiber/epoxy- and glass-f...

Reduced-antigen-content diphtheria-tetanus-acellular pertussis (dTpa) vaccine, Boostrix™, is indicated for booster vaccination of children, adolescents and adults. The original prefilled disposable dTpa syringe presentation was recently replaced by another prefilled-syringe presentation with latex-free tip-caps and plunger-stoppers. 671 healthy adolescents aged 10-15 years who had previously re...

Background. A higher prevalence of cardiovascular disorders has been observed in women after menopause. This study aimed to determine the long-term effects ovariectomy on hemodynamic functions and level nitric oxide metabolites (NOx) heart tissue ovariectomized rats. Methods. Fourteen female Wistar rats were divided into two groups (n=7 each group) control (OVX). OVX rat model was induced using...