We present a currently developed Decision Support Tool Supply Chain (DST-SC). This is specialized domain oriented tool, which is an extension of the general purpose, UML-RT Hybrid Simulation kernel of AnyLogic by XJ Technologies. DST-SC allows high degree of flexibility with respect to the supply chain functionality being modeled, has the ability to handle large complex problems, and offers hig...

OBJECTIVES Phenotypic drug susceptibility testing (DST) for Mycobacterium tuberculosis takes several weeks to complete and second-line DST is often poorly reproducible, potentially leading to compromised clinical decisions. Following a fatal case of XDR TB, we investigated the potential benefit of using whole-genome sequencing to generate an in silico drug susceptibility profile. METHODS The ...

Pretransplantation donor-specific transfusion (DST) can enhance allograft survival in man and animals. However, due to the lack of a specific marker to identify donor-reactive cells in vivo in man and normal (nontransgenic) animals, the underlying mechanism remains unknown. In this study, we use 2CF1 transgenic mice expressing a transgenic T-cell receptor (TCR) specifically recognizing Ld, a ma...

In this study, DNA microarray analysis was used to expand our understanding of the dst1 mutant of Arabidopsis. The dst (downstream) mutants were isolated originally as specifically increasing the steady state level and the half-life of DST-containing transcripts. As such, txhey offer a unique opportunity to study rapid sequence-specific mRNA decay pathways in eukaryotes. These mutants show a th...

Mathematical Theory of Evidence called also Dempster-Shafer Theory (DST) is known as a foundation for reasoning when knowledge is expressed at various levels of detail. Though much research effort has been committed to this theory since its foundation, many questions remain open. One of the most important open questions seems to be the relationship between frequencies and the Mathematical Theor...

The association between abnormal Dexamethasone Suppression Test (DST) and sleep electroencephalographic (EEG) findings and depressives’ response to active drug treatment is equivocal. Recently, however, investigators have attempted to determine the relationship between these measures and response to somatic versus nonsomatic treatment. Carroll (1985) has reported that DST nonsuppressors are not...

We assessed the length and the quality of remission of 13 unipolar endogenous depressed patients, DST non-suppressors before treatment, in a 2-year prospective study. During this period, we recorded stressful life events. Persistent dexamethasone non-suppression, after treatment and complete clinical recovery, correlated highly with early clinical relapse. All six non-normalizers but only one n...

1. Fever and leukocytosis are occasionally observed in patients with psychiatric disorders. A thorough medical evaluation does not always reveal the origin of these abnormalities. 2. We report the case histories of three patients with bipolar affective disorder and an abnormal DST who had fever and leukocytosis during the acute phase of their illness. No organic etiology could be found. 3. All ...

The dexamethasone suppression test (DST) was performed in 38 patients satisfying the Research Diagnostic Criteria (RDC) for cortisol, human growth hormone (hGH), prolactin, triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined at 4:00 p.m. before the administration of dexamethasone, whereas cortisol, hGH and TSH were determined at 4:00 p.m. the day after. A...

The Discrete Sine and Cosine Transforms (DST and DCT) have already received considerable attention due to their use in source coding. The DCT of type-II (DCT-II) is at the core of standards for image and video compression, such as JPEG, H.26x-series, and MPEG 1-4 standards. The DST of type-I was suggested as a basis for Recursive Block Coding technique. The DCT and DST of type IV are used in de...