نتایج جستجو برای: ds graph

تعداد نتایج: 215912  

Cationic polymeric nanoparticles have great potential for developing drug delivery systemswith limited side effects for tumor medication. The goal of this research is investigation ofcationic dextran-spermine polymer (DS) efficacy for improvement of hydrophilic drug deliveryto negatively charged cancerous cells. Capecitabine (as a hydrophilic antineoplastic drug) wasloaded into the magnetic dex...

2017
Zhipeng Wang Jiao Tan Christopher McConville Vinodh Kannappan Patricia Erebi Tawari James Brown Jin Ding Angel L. Armesilla Juan M. Irache Qi-Bing Mei Yuhuan Tan Ying Liu Wenguo Jiang Xiu-Wu Bian Weiguang Wang

Disulfiram (DS), an anti-alcoholism drug, shows very strong cytotoxicity in many cancer types. However its clinical application in cancer treatment is limited by the very short half-life in the bloodstream. In this study, we developed a poly lactic-co-glycolic acid (PLGA)-encapsulated DS protecting DS from the degradation in the bloodstream. The newly developed DS-PLGA was characterized. The DS...

2015
Patricia Erebi Tawari Zhipeng Wang Mohammad Najlah Chi Wai Tsang Vinodh Kannappan Peng Liu Christopher McConville Bin He Angel L. Armesilla Weiguang Wang

The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity in...

Journal: :I. J. Network Security 2011
Nikolay A. Moldovyan

Using Russian digital signature (DS) standards as the underlying scheme there are designed the blind DS protocols that are the first known implementation of the blind DS based on signature standards. There are also proposed blind collective DS protocols based on the DS standards. The last protocols are also the first implementation of the blind multi-signature schemes using the signature verifi...

Journal: :Journal of High Energy Physics 2019

Journal: :Immunology & Cell Biology 2013

Journal: :Physical review 2023

In the framework of static patch approach to de Sitter holography introduced in [L. Susskind, J. Hologr. Appl. Phys. 1, 1 (2021)], growth holographic complexity has a hyperfast behavior, which leads divergence finite time. This is very different from anti--de (AdS) spacetime, where instead rate asymptotically reaches constant value. We study volume class AdS geometries include bubbles their int...

Journal: :The Plant journal : for cell and molecular biology 1999
H G Chin M S Choe S H Lee S H Park J C Koo N Y Kim J J Lee B G Oh G H Yi S C Kim H C Choi M J Cho C D Han

In rice, limited efforts have been made to identify genes by the use of insertional mutagens, especially heterologous transposons such as the maize Ac/Ds. We constructed Ac and gene trap Ds vectors and introduced them into the rice genome by Agrobacterium-mediated transformation. In this report, rice plants that contained single and simple insertions of T-DNA were analysed in order to evaluate ...

2016
A.-L. Lin D. Powell A. Caban-Holt G. Jicha W. Robertson B.T. Gold R. Davis E. Abner D.M. Wilcock F.A. Schmitt E. Head

To determine if proton magnetic resonance spectroscopy ((1)H-MRS) detect differences in dementia status in adults with Down syndrome (DS), we used (1)H-MRS to measure neuronal and glial metabolites in the posterior cingulate cortex in 22 adults with DS and in 15 age- and gender-matched healthy controls. We evaluated associations between (1)H-MRS results and cognition among DS participants. Neur...

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